SCHEMBL6510262

SCHEMBL6510262

C#Cc1ccccc1-c1ccc(C#C[Si](C)(C)C)nc1

nearest known ligand 0.33

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 1/20 0.33
MEN1 O00255 1/20 0.33
ALDH1A1 P00352 1/20 0.33
CYP1A2 P05177 1/20 0.33
CYP3A4 P08684 1/20 0.33
CYP2D6 P10635 1/20 0.33
MAPT P10636 1/20 0.33
CYP2C9 P11712 1/20 0.33
HPGD P15428 1/20 0.33
TSHR P16473 1/20 0.33
CYP2C19 P33261 1/20 0.33
KMT2A Q03164 1/20 0.33
HSD17B10 Q99714 1/20 0.33
ESR2 Q92731 1/20 0.31
KLKB1 P03952 1/20 0.31
BACE1 P56817 1/20 0.31
GRM5 P41594 2/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6513126 0.79 FFAR1 (0.35) KDM4EMEN1ALDH1A1CYP1A2CYP3A4
SCHEMBL29471995 0.78 BACE1 (0.40) CYP2D6BACE1GRM5
SCHEMBL22531721 0.78 BACE1 (0.40) CYP2D6BACE1GRM5
SCHEMBL6510422 0.73 BACE1 (0.36) KDM4EMEN1ALDH1A1CYP1A2CYP3A4
SCHEMBL18015337 0.71 LDHA (0.45)
SCHEMBL6511906 0.70 ALDH1A1 (0.40) KDM4EMEN1ALDH1A1CYP1A2CYP3A4
SCHEMBL2322584 0.69 MCHR1 (0.45) MEN1CYP1A2CYP3A4CYP2D6MAPT
SCHEMBL21097451 0.68 GRM5 (0.49) KDM4EMEN1ALDH1A1CYP1A2CYP3A4
SCHEMBL19453039 0.68 HCAR2 (0.34) ESR2GRM5
SCHEMBL9088916 0.67 GRM5 (0.42) KDM4EMEN1ALDH1A1CYP1A2CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20050101063-A1 Three-terminal field-controlled molecular devices TOUR JAMES M (US) 2005-05-12 US disclosed
WO-2002035580-A2 THREE-TERMINAL FIELD-CONTROLLED MOLECULAR DEVICES MOLECULAR ELECTRONICS CORPORATION (US) 2002-05-02 WO disclosed