Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 4/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.38 |
| ▸ | MTOR | P42345 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | GRM5 | P41594 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.35 |
| ▸ | GSK3A | P49840 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14564232 | 0.81 | MEN1 (0.41) | NOTUMTSHRMAPK1KDM4EL3MBTL1 | |
| SCHEMBL16713034 | 0.81 | PTGS2 (0.51) | PTGS2NOTUMPIK3CAMTORTSHR | |
| SCHEMBL11378909 | 0.79 | ATM (0.43) | TSHRKDM4EALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL3830999 | 0.77 | PTGS2 (0.52) | PTGS2PIK3CAMTORTSHRKDM4E | |
| SCHEMBL23147167 | 0.76 | KDM4E (0.46) | PTGS2NOTUMTSHRGRM5KDM4E | |
| SCHEMBL14248834 | 0.76 | TDP1 (0.48) | PTGS2NOTUMMAPK1GRM5KDM4E | |
| SCHEMBL14249127 | 0.74 | PTGS2 (0.34) | PTGS2TSHRMAPK1GRM5L3MBTL1 | |
| SCHEMBL14249281 | 0.72 | POLB (0.47) | TSHRMAPK1KDM4EALDH1A1POLB | |
| SCHEMBL12247832 | 0.71 | MEN1 (0.49) | PTGS2PIK3CAMTORTSHRMAPK1 | |
| SCHEMBL11286754 | 0.71 | NOTUM (0.38) | PTGS2NOTUMPIK3CAMTORTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050036993-A1 | Immune activation by double-stranded polynucleotides | KOHN LEONARD D (US) | 2005-02-17 | — | — | US | disclosed |
| US-20020142974-A1 | IMMUNE ACTIVATION BY DOUBLE-STRANDED POLYNUCLEOTIDES | SENTRON MEDICAL, INC. | 2002-10-03 | — | — | US | disclosed |
| US-6365616-B1 | TRANSPLANT REJECTION | SENTRON MEDICAL, INC. | 2002-04-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050036993-A1 | Immune activation by double-stranded polynucleotides | MICA, CD74, HLA-DRB1 | PTGS2 1585/4885NOTUM 4474/4885PIK3CA 2821/4885 |
| US-20020142974-A1 | IMMUNE ACTIVATION BY DOUBLE-STRANDED POLYNUCLEOTIDES | MICA, CD74, HLA-DRB1 | PTGS2 1585/4885NOTUM 4474/4885PIK3CA 2821/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.