Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR52 | Q9Y2T5 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | UBE2M | P61081 | 4/20 | 0.39 |
| ▸ | DCUN1D1 | Q96GG9 | 4/20 | 0.39 |
| ▸ | CRHR1 | P34998 | 3/20 | 0.39 |
| ▸ | JAK2 | O60674 | 2/20 | 0.38 |
| ▸ | JAK1 | P23458 | 2/20 | 0.38 |
| ▸ | TYK2 | P29597 | 2/20 | 0.38 |
| ▸ | JAK3 | P52333 | 2/20 | 0.38 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.38 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.37 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.37 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL650510 | 0.94 | PIN1 (0.41) | MEN1KMT2AUBE2MDCUN1D1CRHR1 | |
| SCHEMBL649253 | 0.89 | SQLE (0.38) | CRHR1JAK2JAK1TYK2JAK3 | |
| SCHEMBL651093 | 0.89 | CRHR1 (0.37) | CRHR1JAK2JAK1TYK2JAK3 | |
| SCHEMBL649162 | 0.88 | CRHR1 (0.46) | CRHR1JAK2JAK1TYK2JAK3 | |
| SCHEMBL651143 | 0.87 | CRHR1 (0.37) | CRHR1JAK2JAK1TYK2JAK3 | |
| SCHEMBL648691 | 0.86 | RORC (0.41) | CRHR1JAK2JAK1TYK2JAK3 | |
| SCHEMBL648929 | 0.86 | C5AR1 (0.55) | MEN1KMT2AUBE2MDCUN1D1C5AR1 | |
| SCHEMBL651157 | 0.85 | JAK2 (0.36) | CRHR1JAK2JAK1TYK2JAK3 | |
| SCHEMBL649676 | 0.85 | CRHR1 (0.41) | KMT2ACRHR1JAK2JAK1TYK2 | |
| SCHEMBL650398 | 0.84 | CRHR1 (0.48) | CRHR1C5AR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8119665-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD. (BM) | 2012-02-21 | — | — | US | disclosed |
| US-8119665-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD. (BM) | 2012-02-21 | — | — | US | disclosed |
| US-8119665-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD. (BM) | 2012-02-21 | — | — | US | disclosed |
| US-7186734-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NEUROGEN CORPORATION (US) | 2007-03-06 | — | — | US | disclosed |
| US-7186734-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NEUROGEN CORPORATION (US) | 2007-03-06 | — | — | US | disclosed |
| US-7186734-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NEUROGEN CORPORATION (US) | 2007-03-06 | — | — | US | disclosed |