Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.54 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.50 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.49 |
| ▸ | CASP2 | P42575 | 2/20 | 0.48 |
| ▸ | CA12 | O43570 | 2/20 | 0.48 |
| ▸ | F13A1 | P00488 | 2/20 | 0.48 |
| ▸ | CA2 | P00918 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.48 |
| ▸ | CA4 | P22748 | 2/20 | 0.48 |
| ▸ | CA6 | P23280 | 2/20 | 0.48 |
| ▸ | CA5A | P35218 | 2/20 | 0.48 |
| ▸ | THPO | P40225 | 2/20 | 0.48 |
| ▸ | CA7 | P43166 | 2/20 | 0.48 |
| ▸ | CA9 | Q16790 | 2/20 | 0.48 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.48 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15295964 | 1.00 | ACE2 (0.54) | ACE2HRH3SCN5ACASP2CA12 | |
| SCHEMBL4361290 | 1.00 | ACE2 (0.54) | ACE2HRH3SCN5ACASP2CA12 | |
| SCHEMBL6506342 | 1.00 | ACE2 (0.54) | ACE2HRH3SCN5ACASP2CA12 | |
| SCHEMBL10939162 | 0.98 | ACE2 (0.56) | ACE2HRH3SCN5ACASP2CA12 | |
| SCHEMBL10936965 | 0.94 | ACE2 (0.57) | ACE2HRH3SCN5ACASP2CA12 | |
| SCHEMBL8307200 | 0.94 | ACE2 (0.61) | ACE2HRH3SCN5ACA12CA2 | |
| SCHEMBL8308932 | 0.92 | ACE2 (0.65) | ACE2HRH3SCN5ACASP2CA12 | |
| SCHEMBL8310662 | 0.91 | ACE2 (0.64) | ACE2HRH3SCN5ACA12CA2 | |
| Motuporamine C SCHEMBL6511891 | 0.89 | SCN5A (0.46) | ACE2HRH3SCN5ACASP2CA12 | |
| Motuporamine C SCHEMBL187465 | 0.89 | SCN5A (0.46) | ACE2HRH3SCN5ACASP2CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2831034-B1 | ANTI-METASTATIC AGENTS PREDICATED UPON POLYAMINE-MACROCYCLIC CONJUGATES | UNIV CENTRAL FLORIDA RES FOUND INC (US) | 2019-07-31 | — | — | EP | disclosed |
| US-9266815-B2 | Anti-metastatic agents predicated upon polyamine macrocyclic conjugates | UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. (US) | 2016-02-23 | — | — | US | disclosed |
| US-9266815-B2 | Anti-metastatic agents predicated upon polyamine macrocyclic conjugates | UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. (US) | 2016-02-23 | — | — | US | disclosed |
| US-20150057361-A1 | ANTI-METASTATIC AGENTS PREDICATED UPON POLYAMINE MACROCYCLIC CONJUGATES | UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. (US) | 2015-02-26 | — | — | US | disclosed |
| US-20150057361-A1 | ANTI-METASTATIC AGENTS PREDICATED UPON POLYAMINE MACROCYCLIC CONJUGATES | UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. (US) | 2015-02-26 | — | — | US | disclosed |
| WO-2013148219-A1 | ANTI-METATSTATIC AGENTS PREDICATED UPON POLYAMINE-MACROCYCLIC CONJUGATES | UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. (US) | 2013-10-03 | — | — | WO | disclosed |
| US-20100240747-A1 | Motuporamine Mimic Agents | PHANSTIEL OTTO | 2010-09-23 | — | — | US | disclosed |
| US-7728041-B2 | Motuporamine mimic agents | UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. (US) | 2010-06-01 | — | — | US | disclosed |
| US-20090069441-A1 | Motuporamine Mimic Agents | UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. | 2009-03-12 | — | — | US | disclosed |
| US-20070213397-A1 | Motuporamine mimic agents | UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. | 2007-09-13 | — | — | US | disclosed |
| US-20050222126-A1 | Antiangiogenic compounds and an assay for inhibitors of cell invasion | THE UNIVERSITY OF BRITISH COLUMBIA (CA) | 2005-10-06 | — | — | US | disclosed |
| EP-1355893-A2 | ANTIANGIOGENIC COMPOUNDS AND AN ASSAY FOR INHIBITORS OF CELL INVASION | The University of British Columbia (CA) | 2003-10-29 | — | — | EP | disclosed |
| US-20030004149-A1 | Antiangiogenic compounds and an assay for inhibitors of cell invasion | UNIVERSITY OF BRITISH COLUMBIA, THE (CA) | 2003-01-02 | — | — | US | disclosed |
| WO-2002058679-A2 | ANTIANGIOGENIC COMPOUNDS AND AN ASSAY FOR INHIBITORS OF CELL INVASION | THE UNIVERSITY OF BRITISH COLUMBIA (CA) | 2002-08-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100240747-A1 | Motuporamine Mimic Agents | MYADM, CD99, HNMT | ACE2 4190/4885HRH3 949/4885SCN5A 4486/4885 |
| US-20030004149-A1 | Antiangiogenic compounds and an assay for inhibitors of cell invasion | MKI67, FLT4, DCX | ACE2 3397/4885HRH3 1274/4885SCN5A 4193/4885 |
| US-20150057361-A1 | ANTI-METASTATIC AGENTS PREDICATED UPON POLYAMINE MACROCYCLIC CONJUGATES | NUDC, SLC7A1, HNMT | ACE2 4641/4885HRH3 677/4885SCN5A 4778/4885 |
| US-20070213397-A1 | Motuporamine mimic agents | MYADM, CD99, HNMT | ACE2 4190/4885HRH3 949/4885SCN5A 4486/4885 |
| US-20050222126-A1 | Antiangiogenic compounds and an assay for inhibitors of cell invasion | MKI67, FLT4, DCX | ACE2 3397/4885HRH3 1274/4885SCN5A 4193/4885 |
| US-20090069441-A1 | Motuporamine Mimic Agents | MYADM, CD99, HNMT | ACE2 4190/4885HRH3 949/4885SCN5A 4486/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.