Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 3/20 | 0.56 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.54 |
| ▸ | GPR139 | Q6DWJ6 | 4/20 | 0.53 |
| ▸ | CES2 | O00748 | 1/20 | 0.53 |
| ▸ | CES1 | P23141 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 4/20 | 0.53 |
| ▸ | RAB9A | P51151 | 4/20 | 0.53 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | PARP1 | P09874 | 1/20 | 0.50 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.50 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.50 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14347656 | 0.87 | NPC1 (0.51) | PTGS1TRPM8GPR139CES2CES1 | |
| SCHEMBL24054972 | 0.87 | MEN1 (0.49) | PTGS1CES2CES1NPC1RAB9A | |
| SCHEMBL11538804 | 0.85 | PTGS2 (0.70) | PTGS1PTGS2MEN1KMT2AMAPT | |
| SCHEMBL8622126 | 0.84 | CES2 (0.61) | TRPM8GPR139CES2CES1NPC1 | |
| SCHEMBL16781980 | 0.84 | TDP1 (0.62) | TRPM8GPR139CES2CES1NPC1 | |
| SCHEMBL361183 | 0.83 | PTGS1 (0.73) | PTGS1CES2CES1PTGS2MEN1 | |
| SCHEMBL10629616 | 0.83 | PTGS1 (0.73) | PTGS1CES2CES1PTGS2MEN1 | |
| SCHEMBL31635557 | 0.83 | PTGS1 (0.73) | PTGS1CES2CES1PTGS2MEN1 | |
| SCHEMBL15641441 | 0.83 | PTGS1 (0.73) | PTGS1CES2CES1PTGS2MEN1 | |
| SCHEMBL11754345 | 0.83 | CES2 (0.51) | TRPM8GPR139CES2CES1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016016414-A1 | METHOD FOR CREATING UNCATALYZED CARBON-CARBON BONDS FROM CARBONYLATED COMPOUNDS | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S) (FR) | 2016-02-04 | — | — | WO | disclosed |
| US-9243011-B2 | Dialkyl(2-alkoxy-6-aminophenyl)phosphine, the preparation method and use thereof | ZHEJIANG UNIVERSITY (CN) | 2016-01-26 | — | — | US | disclosed |
| US-9243011-B2 | Dialkyl(2-alkoxy-6-aminophenyl)phosphine, the preparation method and use thereof | ZHEJIANG UNIVERSITY (CN) | 2016-01-26 | — | — | US | disclosed |
| US-20140309422-A1 | DIALKYL(2-ALKOXY-6-AMINOPHENYL)PHOSPHINE, THE PREPARATION METHOD AND USE THEREOF | ZHEJIANG UNIVERSITY (CN) | 2014-10-16 | — | — | US | disclosed |
| US-20140309422-A1 | DIALKYL(2-ALKOXY-6-AMINOPHENYL)PHOSPHINE, THE PREPARATION METHOD AND USE THEREOF | ZHEJIANG UNIVERSITY (CN) | 2014-10-16 | — | — | US | disclosed |
| CN-101717408-B | Phosphonium salt compound containing precursor of biphosphorus ylide cyclopentadienyl cyclocarbene as well as preparation method and application thereof | UNIV LUOYANG NORMAL | 2013-04-03 | — | — | CN | disclosed |
| CN-101717408-A | Phosphonium salt compound containing precursor of biphosphorus ylide cyclopentadienyl cyclocarbene as well as preparation method and application thereof | UNIV LUOYANG NORMAL | 2010-06-02 | — | — | CN | disclosed |
| US-6867310-B1 | Arylation and vinylation of activated carbons | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2005-03-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140309422-A1 | DIALKYL(2-ALKOXY-6-AMINOPHENYL)PHOSPHINE, THE PREPARATION METHOD AND USE THEREOF | DCLK1, DCLK2, CILK1 | PTGS1 4322/4885TRPM8 3366/4885GPR139 2022/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.