SCHEMBL5365528

SCHEMBL5365528

CCc1ccc(-c2nc(CCO)c(C)o2)cc1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 3/20 0.57
RAB9A P51151 2/20 0.57
PPARG P37231 4/20 0.53
PPARA Q07869 3/20 0.53
POLB P06746 4/20 0.50
MAPT P10636 4/20 0.50
SMN1; SMN2 Q16637 3/20 0.50
NPSR1 Q6W5P4 1/20 0.48
ALDH1A1 P00352 4/20 0.47
HTT P42858 2/20 0.47
LMNA P02545 1/20 0.47
HPGD P15428 1/20 0.47
MAPK1 P28482 1/20 0.47
HSD17B10 Q99714 1/20 0.47
KMT2A Q03164 3/20 0.47
TP53 P04637 1/20 0.47
MEN1 O00255 2/20 0.46
NCOA3 Q9Y6Q9 1/20 0.46
NPC1 O15118 1/20 0.45
TSHR P16473 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5368869 0.90 KDM4E (0.47) KDM4ERAB9APPARGPPARAPOLB
SCHEMBL3530493 0.89 RAB9A (0.53) KDM4ERAB9APPARGPPARAPOLB
SCHEMBL6511253 0.88 KDM4E (0.60) KDM4ERAB9APPARGPPARAPOLB
SCHEMBL27589269 0.87 KDM4E (0.46) KDM4ERAB9APPARGPPARASMN1; SMN2
SCHEMBL820945 0.86 SMN1; SMN2 (0.51) KDM4ERAB9APPARGPPARAPOLB
SCHEMBL18095717 0.85 PPARG (0.46) KDM4ERAB9APPARGPPARAPOLB
SCHEMBL4888378 0.83 RAB9A (0.62) KDM4ERAB9APPARGPPARALMNA
SCHEMBL1436051 0.83 PPARA (0.51) KDM4ERAB9APPARGPPARAMAPT
SCHEMBL1436227 0.83 HSD17B10 (0.54) KDM4ERAB9APPARGPPARAPOLB
SCHEMBL1981068 0.83 PPARG (0.54) KDM4ERAB9APPARGPPARAPOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025054309-A9 METHODS OF IDENTIFYING AND TREATING PATIENTS HAVING NEURODEGENERATIVE DISEASE BASED ON PLASMA BIOMARKER LEVELS T3D THERAPEUTICS, INC. (US) 2025-05-01 WO disclosed
US-20250099434-A1 METHODS OF TREATING AMYLOID RELATED BRAIN DISORDERS USING NOVEL COMPOUNDS AND ANTIBODIES T3D THERAPEUTICS, INC. 2025-03-27 US disclosed
WO-2025054309-A1 METHODS OF IDENTIFYING AND TREATING PATIENTS HAVING NEURODEGENERATIVE DISEASE BASED ON PLASMA BIOMARKER LEVELS T3D THERAPEUTICS, INC. (US) 2025-03-13 WO disclosed
WO-2025024308-A1 METHODS OF TREATING ENDOTHELIAL CELL AND AMYLOID RELATED BRAIN DISORDERS USING NOVEL COMPOUNDS AND ANTIBODIES T3D THERAPEUTICS, INC. (US) 2025-01-30 WO disclosed
WO-2023146818-A2 METHODS OF TREATING AMYLOID RELATED BRAIN DISORDERS USING NOVEL COMPOUNDS AND ANTIBODIES T3D THERAPEUTICS, INC. (US) 2023-08-03 WO disclosed
WO-2023146818-A2 METHODS OF TREATING AMYLOID RELATED BRAIN DISORDERS USING NOVEL COMPOUNDS AND ANTIBODIES T3D THERAPEUTICS, INC. (US) 2023-08-03 WO disclosed
US-20210369680-A1 METHODS OF TREATING DISEASES AND DISORDERS RESULTING FROM BETA CORONAVIRUS INFECTION T3D THERAPEUTICS INC (US) 2021-12-02 US disclosed
US-20210369680-A1 METHODS OF TREATING DISEASES AND DISORDERS RESULTING FROM BETA CORONAVIRUS INFECTION T3D THERAPEUTICS INC (US) 2021-12-02 US disclosed
US-20210212996-A1 METHODS OF TREATING NEURODEGENERATIVE DISEASES USING INDANE ACETIC ACID DERIVATIVES WHICH PENETRATE THE BLOOD BRAIN BARRIER DARA BIOSCIENCES, INC. (US) 2021-07-15 US disclosed
US-20210212996-A1 METHODS OF TREATING NEURODEGENERATIVE DISEASES USING INDANE ACETIC ACID DERIVATIVES WHICH PENETRATE THE BLOOD BRAIN BARRIER DARA BIOSCIENCES, INC. (US) 2021-07-15 US disclosed
US-20180117013-A1 METHODS OF TREATING LIVER DISEASE USING INDANE ACETIC ACID DERIVATIVES T3D THERAPEUTICS, INC. (US) 2018-05-03 US disclosed
US-20180117013-A1 METHODS OF TREATING LIVER DISEASE USING INDANE ACETIC ACID DERIVATIVES T3D THERAPEUTICS, INC. (US) 2018-05-03 US disclosed
US-20180117013-A1 METHODS OF TREATING LIVER DISEASE USING INDANE ACETIC ACID DERIVATIVES T3D THERAPEUTICS, INC. (US) 2018-05-03 US disclosed
EP-3273964-A1 METHODS OF TREATING LIVER DISEASE USING INDANE ACETIC ACID DERIVATIVES T3D Therapeutics Inc. (US) 2018-01-31 EP disclosed
WO-2016154258-A1 METHODS OF TREATING LIVER DISEASE USING INDANE ACETIC ACID DERIVATIVES T3D THERAPEUTICS, INC. (US) 2016-09-29 WO disclosed
WO-2016154258-A1 METHODS OF TREATING LIVER DISEASE USING INDANE ACETIC ACID DERIVATIVES T3D THERAPEUTICS, INC. (US) 2016-09-29 WO disclosed
US-7241784-B2 Carboxylic acid derivative and a pharmaceutical composition containing the derivative as active ingredient ONO PHARMACEUTICAL CO., LTD. (JP) 2007-07-10 US disclosed
US-20040087636-A1 Carboxylic acid derivative and a pharmaceutical composition containing the derivative as active ingredient ONO PHARMACEUTICAL CO., LTD. 2004-05-06 US disclosed
US-6664281-B1 Oxazol-4-yl-alkoxy- or alkthioxy- functionality; peroxisome proliferator activated receptor regulators ONO PHARMACEUTICAL CO., LTD. (JP) 2003-12-16 US disclosed
EP-1108713-A1 CARBOXYLIC ACID DERIVATIVES AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT ONO PHARMACEUTICAL CO., LTD. (JP) 2001-06-20 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180117013-A1 METHODS OF TREATING LIVER DISEASE USING INDANE ACETIC ACID DERIVATIVES ACAT2, ACAT1, CPT1A KDM4E 4152/4885RAB9A 3568/4885PPARG 14/4885
US-20040087636-A1 Carboxylic acid derivative and a pharmaceutical composition containing the derivative as active ingredient PPARA, PPARG, PPARD KDM4E 2833/4885RAB9A 3543/4885PPARG 2/4885
US-20210212996-A1 METHODS OF TREATING NEURODEGENERATIVE DISEASES USING INDANE ACETIC ACID DERIVATIVES WHICH PENETRATE THE BLOOD BRAIN BARRIER PPARG, PPARA, PPARD KDM4E 4568/4885RAB9A 1945/4885PPARG 1/4885
US-20210369680-A1 METHODS OF TREATING DISEASES AND DISORDERS RESULTING FROM BETA CORONAVIRUS INFECTION PPARD, PPARA, PPARG KDM4E 4710/4885RAB9A 2055/4885PPARG 3/4885
US-20250099434-A1 METHODS OF TREATING AMYLOID RELATED BRAIN DISORDERS USING NOVEL COMPOUNDS AND ANTIBODIES MAPT, APP, IAPP KDM4E 4250/4885RAB9A 2869/4885PPARG 2905/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.