SCHEMBL6511540

SCHEMBL6511540

C#Cc1ccc(-c2ccccc2C#C)cc1NC(C)=O

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC1 Q13547 3/20 0.46
KDM4E B2RXH2 2/20 0.46
APOBEC3A P31941 1/20 0.46
GFER P55789 1/20 0.46
APOBEC3G Q9HC16 1/20 0.46
HDAC3 O15379 2/20 0.44
HDAC2 Q92769 2/20 0.44
NPC1 O15118 3/20 0.44
RAB9A P51151 3/20 0.44
MAPT P10636 2/20 0.44
POLB P06746 1/20 0.44
MAOA P21397 2/20 0.39
ALDH1A1 P00352 3/20 0.39
HPGD P15428 1/20 0.39
CYP1A2 P05177 1/20 0.38
CYP3A4 P08684 1/20 0.38
CYP2D6 P10635 1/20 0.38
CYP2C9 P11712 1/20 0.38
CYP2C19 P33261 1/20 0.38
SMN1; SMN2 Q16637 3/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6509230 0.88 RXFP1 (0.44) HDAC1KDM4EAPOBEC3AGFERAPOBEC3G
SCHEMBL6511906 0.88 ALDH1A1 (0.40) HDAC1KDM4EAPOBEC3AGFERAPOBEC3G
SCHEMBL3048096 0.80 ALDH1A1 (0.55) NPC1RAB9AMAPTPOLBMAOA
SCHEMBL8082374 0.74 KDM4E (0.53) HDAC1KDM4ENPC1RAB9AMAPT
SCHEMBL7019611 0.72 ALDH1A1 (0.47) HDAC1KDM4EAPOBEC3AGFERAPOBEC3G
SCHEMBL7021887 0.71 HDAC1 (0.48) HDAC1HDAC3HDAC2NPC1RAB9A
SCHEMBL13758180 0.71 HDAC1 (0.63) HDAC1KDM4EAPOBEC3AGFERAPOBEC3G
SCHEMBL7707267 0.71 ALDH1A1 (0.61) HDAC1KDM4ENPC1RAB9AMAPT
SCHEMBL6509952 0.68 AR (0.36) KDM4EMAPTALDH1A1HPGDLMNA
SCHEMBL29051242 0.68 ESR2 (0.38)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20050101063-A1 Three-terminal field-controlled molecular devices TOUR JAMES M (US) 2005-05-12 US disclosed
WO-2002035580-A2 THREE-TERMINAL FIELD-CONTROLLED MOLECULAR DEVICES MOLECULAR ELECTRONICS CORPORATION (US) 2002-05-02 WO disclosed