Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNE1 | P24864 | 10/20 | 0.33 |
| ▸ | CDK2 | P24941 | 10/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.33 |
| ▸ | CCNE2 | O96020 | 4/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.32 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.32 |
| ▸ | CSF1R | P07333 | 1/20 | 0.32 |
| ▸ | PRKACA | P17612 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
| ▸ | CDK8 | P49336 | 1/20 | 0.32 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.32 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.32 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.32 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.32 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.32 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.32 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.31 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.31 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20767747 | 0.75 | CDK8 (0.36) | ADORA3CHEK1MAP4K4CSF1RPRKACA | |
| SCHEMBL1104796 | 0.67 | ROCK1 (0.46) | CDK2ADORA3CHEK1MAP4K4CSF1R | |
| SCHEMBL11536510 | 0.67 | ROCK1 (0.46) | CDK2ADORA3CHEK1MAP4K4CSF1R | |
| SCHEMBL12638559 | 0.67 | MAP3K14 (0.38) | CHEK1MAP4K4CSF1RPRKACAKDR | |
| SCHEMBL8145613 | 0.66 | PRKCI (0.44) | ADORA3CHEK1MAP4K4CSF1RPRKACA | |
| SCHEMBL1599283 | 0.66 | MAPT (0.38) | CHEK1MAP4K4CSF1RPRKACAKDR | |
| SCHEMBL29242590 | 0.65 | BRD4 (0.45) | ADORA3CHEK1MAP4K4CSF1RPRKACA | |
| SCHEMBL31732605 | 0.64 | MAPK8 (0.43) | — | |
| SCHEMBL8136927 | 0.64 | CYP1A2 (0.51) | — | |
| SCHEMBL557383 | 0.64 | MAP2K1 (0.44) | CCNE1CDK2ADORA3CCNE2CHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005105814-A1 | TETRACYCLIC INHIBITORS OF JANUS KINASES | INCYTE CORPORATION (US) | 2005-11-10 | — | — | WO | claimed |