SCHEMBL6512448

SCHEMBL6512448

COc1ccc(-c2nc(-c3ccc(OC)cc3)nc(-c3ccccc3O)n2)cc1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 7/20 0.57
RAB9A P51151 4/20 0.57
ALOX15 P16050 2/20 0.57
TSHR P16473 2/20 0.57
ADORA3 P0DMS8 1/20 0.57
ADORA2A P29274 1/20 0.57
ADORA2B P29275 1/20 0.57
ADORA1 P30542 1/20 0.57
MEN1 O00255 4/20 0.54
KMT2A Q03164 4/20 0.54
MAPT P10636 4/20 0.54
ATM Q13315 1/20 0.54
LMNA P02545 4/20 0.54
NFKB1 P19838 3/20 0.54
NFKB2 Q00653 3/20 0.54
RELA Q04206 3/20 0.54
ALOX12 P18054 2/20 0.54
KDM4E B2RXH2 2/20 0.54
SMN1; SMN2 Q16637 3/20 0.52
HPGD P15428 2/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16746693 1.00 NPC1 (0.57) NPC1RAB9AALOX15TSHRADORA3
SCHEMBL15909996 1.00 NPC1 (0.57) NPC1RAB9AALOX15TSHRADORA3
SCHEMBL39029 0.97 ALOX15 (0.62) NPC1RAB9AALOX15TSHRADORA3
SCHEMBL29364346 0.97 ALOX15 (0.62) NPC1RAB9AALOX15TSHRADORA3
SCHEMBL4027746 0.95 ALOX15 (0.60) NPC1RAB9AALOX15TSHRADORA3
SCHEMBL15908123 0.94 MAPT (0.56) NPC1RAB9AALOX15TSHRADORA3
SCHEMBL13938597 0.94 ALOX15 (0.59) NPC1RAB9AALOX15TSHRADORA3
SCHEMBL13299328 0.94 MAPT (0.56) NPC1RAB9AALOX15TSHRADORA3
SCHEMBL12216379 0.93 NPC1 (0.51) NPC1RAB9AALOX15TSHRADORA3
SCHEMBL13299331 0.93 NR1H4 (0.57) NPC1RAB9AALOX15TSHRADORA3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 44 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-8337574-A None JP disclosed
JP-7233154-A None JP disclosed
US-20170189277-A1 COMPOSITE PIGMENT AND METHOD FOR PREPARATION THEREOF L'OREAL (FR) 2017-07-06 US disclosed
US-20170189277-A1 COMPOSITE PIGMENT AND METHOD FOR PREPARATION THEREOF L'OREAL (FR) 2017-07-06 US disclosed
US-9669243-B2 Delivery of hydrophobic benefit agents from bodywashes and the like onto a keratinous substrate BASF SE (DE) 2017-06-06 US disclosed
US-20150190320-A1 COSMETIC COMPOSITION COMPRISING COMPOSITE SUNSCREEN PARTICLES L'OREAL (FR) 2015-07-09 US disclosed
US-20150190320-A1 COSMETIC COMPOSITION COMPRISING COMPOSITE SUNSCREEN PARTICLES L'OREAL (FR) 2015-07-09 US disclosed
US-20150157539-A1 COSMETIC COMPOSITION COMPRISING COMPOSITE PARTICLES L'OREAL (FR) 2015-06-11 US disclosed
US-20150157539-A1 COSMETIC COMPOSITION COMPRISING COMPOSITE PARTICLES L'OREAL (FR) 2015-06-11 US disclosed
US-8882902-B2 Composite pigment and method for preparation thereof L'OREAL (FR) 2014-11-11 US disclosed
EP-0815071-B1 LIPOSOMOGENIC UV ABSORBERS CIBA SC HOLDING AG (CH) 2001-04-11 EP disclosed
US-6017556-A PROTECTING HUMAN HAIR FROM THE DAMAGING EFFECT OF ULTRAVIOLET RADIATION BY TREATING HUMAN HAIR WITH A LIPOSOMOGENIC ULTRAVIOLET RADIATION ABSORBER CIBA SPECIALTY CHEMICALS CORPORATION (US) 2000-01-25 US disclosed
US-6015575-A TRIAZINE, BENZOTRIAZOLE, BENZOPHENONE AND AMINOBENZOIC ACID DERIVATIVES AS RADIATION ABSORBERS CIBA SPECIALTY CHEMICALS CORPORATION (US) 2000-01-18 US disclosed
EP-0834304-A2 Liposomogenic UV absorbers Ciba SC Holding AG (CH) 1998-04-08 EP disclosed
US-5688995-A SUNSCREEN AGENTS CIBA-GEIGY CORPORATION (US) 1997-11-18 US disclosed
US-5591850-A STABILIZERS FOR TEXTILE FIBERS, COSMETIC SUNSCREENS CIBA-GEIGY CORPORATION (US) 1997-01-07 US disclosed
JP-H08337574-A O-HYDROXYPHENYL-S-TRIAZINE CIBA GEIGY AG 1996-12-24 JP disclosed
EP-0743309-A1 o-Hydroxyphenyl-s-triazines as UV stabilisers CIBA-GEIGY AG (CH) 1996-11-20 EP disclosed
JP-H07233154-A O-HYDROXYPHEHNYL-S-TRIAZINE CIBA GEIGY AG 1995-09-05 JP disclosed
EP-0654469-A1 O-Hydroxyphenyl-s-triazines as stabilisers for polymers CIBA-GEIGY AG (CH) 1995-05-24 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170189277-A1 COMPOSITE PIGMENT AND METHOD FOR PREPARATION THEREOF TYR, RAB5IF, MITF NPC1 1772/4885RAB9A 457/4885ALOX15 2880/4885
US-20150157539-A1 COSMETIC COMPOSITION COMPRISING COMPOSITE PARTICLES MITF, RAB5IF, TYR NPC1 1863/4885RAB9A 1355/4885ALOX15 1680/4885
US-20150190320-A1 COSMETIC COMPOSITION COMPRISING COMPOSITE SUNSCREEN PARTICLES XPA, ERCC1, ERCC4 NPC1 283/4885RAB9A 1540/4885ALOX15 775/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.