SCHEMBL4027746

SCHEMBL4027746

COc1ccc(-c2nc(-c3ccc(-c4ccccc4)cc3)nc(-c3ccccc3O)n2)cc1

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALOX15 P16050 2/20 0.60
TSHR P16473 2/20 0.60
ADORA3 P0DMS8 1/20 0.60
ADORA2A P29274 1/20 0.60
ADORA2B P29275 1/20 0.60
ADORA1 P30542 1/20 0.60
MEN1 O00255 6/20 0.54
KMT2A Q03164 6/20 0.54
ATM Q13315 1/20 0.54
NPC1 O15118 3/20 0.54
RAB9A P51151 3/20 0.54
LMNA P02545 5/20 0.52
MAPT P10636 4/20 0.52
ALOX12 P18054 2/20 0.50
NFKB1 P19838 2/20 0.50
NFKB2 Q00653 2/20 0.50
RELA Q04206 2/20 0.50
KDM4E B2RXH2 2/20 0.50
S1PR1 P21453 1/20 0.50
NR1H4 Q96RI1 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL39029 0.98 ALOX15 (0.62) ALOX15TSHRADORA3ADORA2AADORA2B
SCHEMBL29364346 0.98 ALOX15 (0.62) ALOX15TSHRADORA3ADORA2AADORA2B
SCHEMBL16746693 0.95 NPC1 (0.57) ALOX15TSHRADORA3ADORA2AADORA2B
SCHEMBL6512448 0.95 NPC1 (0.57) ALOX15TSHRADORA3ADORA2AADORA2B
SCHEMBL15909996 0.95 NPC1 (0.57) ALOX15TSHRADORA3ADORA2AADORA2B
SCHEMBL15908123 0.90 MAPT (0.56) ALOX15TSHRADORA3ADORA2AADORA2B
SCHEMBL13299328 0.90 MAPT (0.56) ALOX15TSHRADORA3ADORA2AADORA2B
SCHEMBL13938597 0.90 ALOX15 (0.59) ALOX15TSHRADORA3ADORA2AADORA2B
SCHEMBL17571546 0.90 TSHR (0.59) ALOX15TSHRADORA3ADORA2AADORA2B
SCHEMBL13299331 0.88 NR1H4 (0.57) ALOX15TSHRADORA3ADORA2AADORA2B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1213283-B1 Biphenyl-substituted triazines as light stabilisers CIBA HOLDING INC (CH) 2009-04-29 EP disclosed
US-6919454-B2 Biphenyl-substituted triazines CIBA SPECIALTY CHEMICALS CORP. (US) 2005-07-19 US disclosed
US-20050019281-A1 Biphenyl-substituted triazines FLETCHER IAN JOHN (CH) 2005-01-27 US disclosed
US-6841670-B2 High thermal stability, are used as stabilizers for organic polymers to counter damage thereto caused by light, oxygen and heat, as light stabilizers for textile fiber materials and as sunscreens for the human skin. CIBA SPECIALTY CHEMICALS CORPORATION (US) 2005-01-11 US disclosed
US-20030045444-A1 Biphenyl-substituted triazines FLETCHER IAN JOHN (CH) 2003-03-06 US disclosed
US-6468958-B2 LIGHT, OXYGEN AND HEAT RESISTANCE CIBA SPECIALTY CHEMICALS CORPORATION 2002-10-22 US disclosed
EP-0815089-B1 BIPHENYL-SUBSTITUTED TRIAZINES AS LIGHT STABILIZER CIBA SC HOLDING AG (CH) 2002-09-25 EP disclosed
EP-1213283-A2 Biphenyl-substituted triazines as light stabilisers Ciba SC Holding AG (CH) 2002-06-12 EP disclosed
US-20010039341-A1 Biphenyl-Substituted Triazines FLETCHER IAN JOHN (CH) 2001-11-08 US disclosed
US-5998116-A TRIAZINE UV ABSORBERS CIBA SPECIALTY CHEMICALS CORPORATION (US) 1999-12-07 US disclosed
EP-0815089-A1 BIPHENYL-SUBSTITUTED TRIAZINES AS LIGHT STABILIZER Ciba SC Holding AG (CH) 1998-01-07 EP disclosed
WO-1996028431-A1 BIPHENYL-SUBSTITUTED TRIAZINES AS LIGHT STABILIZER CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) 1996-09-19 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050019281-A1 Biphenyl-substituted triazines TYR, AHR, CUTA ALOX15 259/4885TSHR 3041/4885ADORA3 4147/4885
US-20030045444-A1 Biphenyl-substituted triazines TYR, CYP1B1, NFE2L2 ALOX15 265/4885TSHR 3355/4885ADORA3 4137/4885
US-20010039341-A1 Biphenyl-Substituted Triazines TYR, CYP1B1, NFE2L2 ALOX15 265/4885TSHR 3355/4885ADORA3 4137/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.