Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 4/20 | 0.55 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.52 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.52 |
| ▸ | LTA4H | P09960 | 1/20 | 0.52 |
| ▸ | EGFR | P00533 | 2/20 | 0.51 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.51 |
| ▸ | BCL2 | P10415 | 1/20 | 0.50 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.50 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | MMP2 | P08253 | 1/20 | 0.47 |
| ▸ | MMP9 | P14780 | 1/20 | 0.47 |
| ▸ | MMP14 | P50281 | 1/20 | 0.47 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7231853 | 0.91 | LTB4R (0.53) | ALOX5LTB4RLTB4R2FFAR1ADAMTS5 | |
| SCHEMBL5582719 | 0.90 | MEN1 (0.56) | ALOX5LTA4HEGFRBCL2LMNA | |
| SCHEMBL7241154 | 0.85 | FFAR1 (0.56) | ALOX5LTA4HFFAR1ADAMTS5CHRM4 | |
| SCHEMBL7230615 | 0.85 | LTB4R (0.47) | ALOX5LTB4RLTB4R2FFAR1BCL2 | |
| SCHEMBL5583103 | 0.84 | RAB9A (0.62) | ALOX5LTA4HEGFRLMNAMEN1 | |
| SCHEMBL7240415 | 0.83 | FFAR1 (0.51) | ALOX5FFAR1ADAMTS5CHRM4ALDH1A1 | |
| Hydrochloric Acid SCHEMBL7233188 | 0.83 | FFAR1 (0.53) | ALOX5LTA4HFFAR1ADAMTS5CHRM4 | |
| SCHEMBL7240480 | 0.81 | BCL2 (0.53) | ALOX5LTA4HFFAR1BCL2ADAMTS5 | |
| SCHEMBL11570271 | 0.80 | KCNH2 (0.69) | ALDH1A1LMNAMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL11570396 | 0.79 | KCNH2 (0.67) | ALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6586475-B1 | 5-chloro-N-(2-N,N-diethylamino)ethyl)-2- methoxy-4-(1-naphthoylamino)benzamide and prodrugs, used for prevention of neurodegenarative diseases such as Alzheimer's disease | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2003-07-01 | — | — | US | claimed |
| EP-1132376-A1 | BETA-AMYLOID PROTEIN PRODUCTION/SECRETION INHIBITORS | Takeda Chemical Industries, Ltd. (JP) | 2001-09-12 | — | — | EP | claimed |
| US-20050228020-A1 | Beta secretase inhibitors | MIYAMOTO MASAOMI | 2005-10-13 | — | — | US | disclosed |
| US-20040110743-A1 | -Secretase inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2004-06-10 | — | — | US | disclosed |
| US-6586475-B1 | 5-chloro-N-(2-N,N-diethylamino)ethyl)-2- methoxy-4-(1-naphthoylamino)benzamide and prodrugs, used for prevention of neurodegenarative diseases such as Alzheimer's disease | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2003-07-01 | — | — | US | disclosed |
| EP-1283039-A1 | -SECRETASE INHIBITORS | Takeda Chemical Industries, Ltd. (JP) | 2003-02-12 | — | — | EP | disclosed |
| EP-1132376-A1 | BETA-AMYLOID PROTEIN PRODUCTION/SECRETION INHIBITORS | Takeda Chemical Industries, Ltd. (JP) | 2001-09-12 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050228020-A1 | Beta secretase inhibitors | BACE1, BACE2, APP | ALOX5 2839/4885LTB4R 2001/4885LTB4R2 2808/4885 |
| US-20040110743-A1 | -Secretase inhibitors | BACE1, BACE2, PSEN1 | ALOX5 2490/4885LTB4R 2255/4885LTB4R2 3029/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.