Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R | Q15722 | 1/20 | 0.47 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.47 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.46 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.46 |
| ▸ | BCL2 | P10415 | 2/20 | 0.45 |
| ▸ | GPR88 | Q9GZN0 | 1/20 | 0.45 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.44 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | PPARG | P37231 | 1/20 | 0.42 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | MMP9 | P14780 | 1/20 | 0.41 |
| ▸ | MMP14 | P50281 | 1/20 | 0.41 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.41 |
| ▸ | PPARA | Q07869 | 1/20 | 0.41 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.41 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.41 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7231853 | 0.87 | LTB4R (0.53) | LTB4RLTB4R2ALOX5CHRM4FFAR1 | |
| SCHEMBL6512669 | 0.85 | ALOX5 (0.55) | LTB4RLTB4R2ALOX5CHRM4BCL2 | |
| SCHEMBL7240480 | 0.84 | BCL2 (0.53) | ALOX5CHRM4BCL2FFAR1ADAMTS5 | |
| SCHEMBL21859127 | 0.79 | CHRM4 (0.55) | LTB4RLTB4R2ALOX5CHRM4LMNA | |
| SCHEMBL3014165 | 0.78 | LTB4R (0.67) | LTB4RLTB4R2ALOX5FFAR1PPARG | |
| SCHEMBL7241154 | 0.78 | FFAR1 (0.56) | ALOX5CHRM4FFAR1ADAMTS5LMNA | |
| SCHEMBL5582719 | 0.77 | MEN1 (0.56) | ALOX5BCL2PTPN1LMNANPC1 | |
| SCHEMBL7240415 | 0.76 | FFAR1 (0.51) | ALOX5CHRM4FFAR1ADAMTS5LMNA | |
| Hydrochloric Acid SCHEMBL7233188 | 0.76 | FFAR1 (0.53) | ALOX5CHRM4FFAR1ADAMTS5LMNA | |
| SCHEMBL4798737 | 0.76 | ALOX5 (0.58) | LTB4RLTB4R2ALOX5PPARGPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6586475-B1 | 5-chloro-N-(2-N,N-diethylamino)ethyl)-2- methoxy-4-(1-naphthoylamino)benzamide and prodrugs, used for prevention of neurodegenarative diseases such as Alzheimer's disease | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2003-07-01 | — | — | US | disclosed |
| EP-1132376-A1 | BETA-AMYLOID PROTEIN PRODUCTION/SECRETION INHIBITORS | Takeda Chemical Industries, Ltd. (JP) | 2001-09-12 | — | — | EP | disclosed |