SCHEMBL6513054

SCHEMBL6513054

O=C(Cl)c1ccc(SSc2ccc(C(=O)Cl)cc2)cc1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.46
HPGD P15428 5/20 0.41
LMNA P02545 1/20 0.41
L3MBTL1 Q9Y468 1/20 0.41
HSD17B10 Q99714 5/20 0.37
CYP1A2 P05177 3/20 0.37
CYP2C9 P11712 3/20 0.37
PLK1 P53350 1/20 0.35
TSHR P16473 4/20 0.35
MAPT P10636 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.35
MGLL Q99685 1/20 0.35
TP53 P04637 1/20 0.35
CES2 O00748 1/20 0.35
CES1 P23141 1/20 0.35
CYP2C19 P33261 3/20 0.34
ALOX15 P16050 2/20 0.33
NAPRT Q6XQN6 1/20 0.32
CA1 P00915 2/20 0.32
CA2 P00918 2/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7138086 0.84 HPGD (0.58) ALDH1A1HPGDLMNAL3MBTL1CYP1A2
SCHEMBL20587670 0.83 ALDH1A1 (0.59) ALDH1A1HPGDLMNATSHRMAPT
SCHEMBL68148 0.83 ALDH1A1 (0.59) ALDH1A1HPGDLMNATSHRMAPT
SCHEMBL11120904 0.82 ALDH1A1 (0.45) ALDH1A1HPGDLMNAL3MBTL1HSD17B10
SCHEMBL18633454 0.80 ALDH1A1 (0.43) ALDH1A1HPGDLMNAL3MBTL1CYP1A2
SCHEMBL435246 0.80 PLK1 (0.57) ALDH1A1HPGDLMNAL3MBTL1HSD17B10
SCHEMBL27930542 0.80 ALDH1A1 (0.43) ALDH1A1HPGDLMNAL3MBTL1CYP1A2
SCHEMBL6758498 0.80 ALDH1A1 (0.64) ALDH1A1HPGDLMNATSHRMAPT
Ammonia Solution, Strong SCHEMBL2023211 0.80 ALDH1A1 (0.56) ALDH1A1HPGDLMNATSHRMAPT
SCHEMBL28787222 0.80 ALDH1A1 (0.56) ALDH1A1HPGDLMNATSHRMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 110 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-111440102-B Preparation method of dithiodibenzoamide compound 大连凯飞化学股份有限公司 2022-02-15 CN claimed
US-5342724-A Preparing polyester from diol and diacid wherein one of the monomers has disulfuide linkage, reacting polyester with unsaturated monomer to create addition polymer blocks linked by sulfide group from dislufide linkage EASTMAN KODAK COMPANY (US) 1994-08-30 US claimed
CN-116802774-A Hollow microsphere 株式会社德山 2023-09-22 CN disclosed
CN-111440102-B Preparation method of dithiodibenzoamide compound 大连凯飞化学股份有限公司 2022-02-15 CN disclosed
EP-3645615-B1 METHOD FOR PRODUCING A SILANE, METHOD FOR MODIFYING A SILICA WITH THE SILANE, AND MODIFIED SILICA CONTINENTAL REIFEN DEUTSCHLAND GMBH (DE) 2021-08-11 EP disclosed
EP-3645307-B1 SILANE, RUBBER MIXTURE CONTAINING THE SILANE AND VEHICLE TYRE HAVING THE RUBBER MIXTURE IN AT LEAST ONE COMPONENT CONTINENTAL REIFEN DEUTSCHLAND GMBH (DE) 2021-08-11 EP disclosed
EP-2656882-B1 Golf ball SUMITOMO RUBBER IND (JP) 2021-06-09 EP disclosed
EP-3292893-B1 GOLF BALL SUMITOMO RUBBER IND (JP) 2021-06-09 EP disclosed
US-20210147689-A1 METHOD FOR PRODUCING A SILANE, METHOD FOR MODIFYING A SILICA WITH THE SILANE, AND MODIFIED SILICA CONTINENTAL REIFEN DEUTSCHLAND GMBH (DE) 2021-05-20 US disclosed
US-20200392307-A1 SILANE, RUBBER MIXTURE CONTAINING THE SILANE AND VEHICLE TYRE HAVING THE RUBBER MIXTURE IN AT LEAST ONE COMPONENT CONTINENTAL REIFEN DEUTSCHLAND GMBH (DE) 2020-12-17 US disclosed
US-10858499-B1 Silane, rubber mixture containing the silane and vehicle tyre having the rubber mixture in at least one component CONTINENTAL REIFEN DEUTSCHLAND GMBH (DE) 2020-12-08 US disclosed
US-5929114-A ADMINISTERING ANTIVIRAL COMPOUND WHICH EXTRUDES ZINC FROM NUCLEOCAPSID PROTEIN OF HUMAN IMMUNODEFICIENCY VIRUS WARNER-LAMBERT COMPANY (US) 1999-07-27 US disclosed
US-5734081-A Arylthio compounds WARNER-LAMBERT COMPANY (US) 1998-03-31 US disclosed
US-5668291-A THIOSUBSTITUTED PYRIDINES, TREATMENT OF AIDS AND HIV WARNER-LAMBERT COMPANY (US) 1997-09-16 US disclosed
EP-0775110-A1 ARYLTHIO COMPOUNDS AS ANTIBACTERIAL AND ANTIVIRAL AGENTS WARNER-LAMBERT COMPANY (US) 1997-05-28 EP disclosed
WO-1996004242-A1 ARYLTHIO COMPOUNDS AS ANTIBACTERIAL AND ANTIVIRAL AGENTS WARNER-LAMBERT COMPANY (US) 1996-02-15 WO disclosed
US-5342724-A Preparing polyester from diol and diacid wherein one of the monomers has disulfuide linkage, reacting polyester with unsaturated monomer to create addition polymer blocks linked by sulfide group from dislufide linkage EASTMAN KODAK COMPANY (US) 1994-08-30 US disclosed
US-4717736-A LEUKOTRIENES, GASTRIC CYTOPROTECTION, AMIDO ACIDS AND ESTERS MERCK FROSST CANADA, INC. (CA) 1988-01-05 US disclosed
EP-0150118-B1 ANTAGONISTS OF SLOW REACTING SUBSTANCES OF ANAPHYLAXIS MERCK FROSST CANADA INC. (CA) 1987-09-16 EP disclosed
EP-0150118-A2 Antagonists of slow reacting substances of anaphylaxis MERCK FROSST CANADA INC. (CA) 1985-07-31 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10858499-B1 Silane, rubber mixture containing the silane and vehicle tyre having the rubber mixture in at least one component NR2E1, NR4A1, MSR1 ALDH1A1 3282/4885HPGD 3948/4885LMNA 918/4885
US-20210147689-A1 METHOD FOR PRODUCING A SILANE, METHOD FOR MODIFYING A SILICA WITH THE SILANE, AND MODIFIED SILICA CLCN2, SCNN1A, KCNC1 ALDH1A1 586/4885HPGD 2803/4885LMNA 369/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.