Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Edetic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.64 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.67 |
| ▸ | EYA2 | O00167 | 1/20 | 0.67 |
| ▸ | APP | P05067 | 1/20 | 0.67 |
| ▸ | ACE | P12821 | 1/20 | 0.67 |
| ▸ | BLM | P54132 | 2/20 | 0.64 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.64 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.64 |
| ▸ | LMNA | P02545 | 1/20 | 0.64 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.64 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.64 |
| ▸ | TSHR | P16473 | 1/20 | 0.64 |
| ▸ | DRD1 | P21728 | 1/20 | 0.64 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.64 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.64 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.64 |
| ▸ | DRD3 | P35462 | 1/20 | 0.64 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.64 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Edetic Acid SCHEMBL2768272 | 0.98 | TDP1 (0.70) | TDP1EYA2APPACEBLM | |
| Edetic Acid SCHEMBL333283 | 0.98 | TDP1 (0.70) | TDP1EYA2APPACEBLM | |
| Edetic Acid SCHEMBL1125702 | 0.93 | TDP1 (0.64) | TDP1EYA2APPACEBLM | |
| Edetic Acid SCHEMBL8780347 | 0.91 | TDP1 (0.61) | TDP1EYA2APPACEBLM | |
| Edetic Acid SCHEMBL167796 | 0.91 | TDP1 (0.67) | TDP1EYA2APPACEBLM | |
| Edetic Acid SCHEMBL9797852 | 0.91 | TDP1 (0.67) | TDP1EYA2APPACEBLM | |
| Edetic Acid SCHEMBL7033909 | 0.91 | TDP1 (0.67) | TDP1EYA2APPACEBLM | |
| Edetic Acid SCHEMBL8008457 | 0.88 | TDP1 (0.64) | TDP1EYA2APPACEBLM | |
| Edetic Acid SCHEMBL28673728 | 0.88 | TDP1 (0.64) | TDP1EYA2APPACEBLM | |
| Edetic Acid SCHEMBL28856674 | 0.88 | TDP1 (0.64) | TDP1EYA2APPACEBLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 66 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240060120-A1 | COMPOSITION AND METHODS FOR HYBRIDIZATION | 42 life sciences GmbH & Co. KG (DE) | 2024-02-22 | — | — | US | disclosed |
| US-20180237840-A1 | COMPOSITION AND METHODS FOR HYBRIDIZATION | 42 life sciences GmbH & Co. KG (DE) | 2018-08-23 | — | — | US | disclosed |
| CN-107849601-A | composition and method for hybridization | 42生命科学有限两合公司 | 2018-03-27 | — | — | CN | disclosed |
| EP-2245185-B1 | A MUTATION IN THE REGULATORY REGION OF GJB2 MEDIATES NEONATAL HEARING LOSS WITHIN DFNB1 | MED EL ELEKTROMED GERAETE GMBH (AT) | 2014-04-30 | — | — | EP | disclosed |
| EP-1482048-B1 | SULFOTRANSFERASE, ITS POLYPEPTIDE AND DNA ENCODING THE SAME | SEIKAGAKU KOGYO CO LTD (JP) | 2014-01-29 | — | — | EP | disclosed |
| US-8623625-B2 | Sulfotransferase, peptide thereof and DNA encoding the same | SEIKAGAKU CORPORATION (JP) | 2014-01-07 | — | — | US | disclosed |
| US-8202705-B2 | Sialyltransferase and DNA encoding the same | SEIKAGAKU KOGYO KABUSHIKI KAISHA (JP) | 2012-06-19 | — | — | US | disclosed |
| US-8119344-B2 | Mutation in the regulatory region of GJB2 mediates neonatal hearing loss within DFNB1 | MED-EL ELEKTROMEDIZINISCHE GERAETE GMBH (AT) | 2012-02-21 | — | — | US | disclosed |
| US-20110008844-A1 | SIALYLTRANSFERASE AND DNA ENCODING THE SAME | SAITO MASAKI | 2011-01-13 | — | — | US | disclosed |
| EP-2245185-A1 | A MUTATION IN THE REGULATORY REGION OF GJB2 MEDIATES NEONATAL HEARING LOSS WITHIN DFNB1 | Med-El Elektromedizinische Geräte GmbH (AT) | 2010-11-03 | — | — | EP | disclosed |
| US-6555666-B1 | Isolated human Septin-2 polynucleotide of given sequence | DANA CORPORATION | 2003-04-29 | — | — | US | disclosed |
| US-6555371-B1 | Enzyme which synthesizes ganglioside by transferring sialic acid to a galactose residue of lactosylceramide | SEIKAGAKU KOGYO KABUSHIKI KAISHA (JP) | 2003-04-29 | — | — | US | disclosed |
| EP-1295946-A1 | SULFATE TRANSFERASE AND DNA ENCODING THIS ENZYME | SEIKAGAKU CORPORATION (JP) | 2003-03-26 | — | — | EP | disclosed |
| EP-0960200-A1 | TRANSCRIPTS ENCODING IMMUNOMODULATORY POLYPEPTIDES | GENELABS TECHNOLOGIES, INC. (US) | 1999-12-01 | — | — | EP | disclosed |
| US-5965427-A | A GENE RESPONSIBLE FOR RECOMBINATIONAL REPAIR OF DOUBLE STRANDED BREAKS; TREATMENT AND DIAGNOSIS OF MYELOID LEUKEMIA | GENELABS TECHNOLOGIES, INC. (US) | 1999-10-12 | — | — | US | disclosed |
| EP-0890645-A2 | Sialyltransferase and DNA encoding the same | SEIKAGAKU KOGYO KABUSHIKI KAISHA (JP) | 1999-01-13 | — | — | EP | disclosed |
| US-5821091-A | PERFORMING POLYMERASE CHAIN REACTION AMPLIFICATION ON MESSENGER RNA OR CDNA | GENELABS TECHNOLOGIES, INC. (US) | 1998-10-13 | — | — | US | disclosed |
| WO-1998038306-A1 | TRANSCRIPTS ENCODING IMMUNOMODULATORY POLYPEPTIDES | GENELABS TECHNOLOGIES, INC. (US) | 1998-09-03 | — | — | WO | disclosed |
| WO-1997027284-A2 | HUMAN RAD50 AND SEPTIN-2 GENES AND METHODS OF USE | GENELABS TECHNOLOGIES, INC. (US) | 1997-07-31 | — | — | WO | disclosed |
| WO-1995016043-A1 | CLONING OF ENDOTHELIN CONVERTING ENZYME | ZENECA LIMITED (GB) | 1995-06-15 | — | — | WO | disclosed |