Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 4/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 3/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | APEX1 | P27695 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6530876 | 0.88 | MAPT (0.38) | ALDH1A1SMN1; SMN2HPGDPOLBMAPT | |
| SCHEMBL6510162 | 0.85 | L3MBTL1 (0.35) | ALDH1A1SMN1; SMN2HPGDPOLBMAPT | |
| SCHEMBL6513021 | 0.83 | PDE10A (0.35) | ALDH1A1SMN1; SMN2HPGDMAPTL3MBTL1 | |
| SCHEMBL6513922 | 0.83 | TDP1 (0.38) | ALDH1A1SMN1; SMN2HPGDMAPTTSHR | |
| SCHEMBL6527853 | 0.81 | HTR3E (0.34) | SMN1; SMN2POLBL3MBTL1 | |
| SCHEMBL6508234 | 0.78 | HPGD (0.37) | ALDH1A1SMN1; SMN2HPGDPOLBMAPT | |
| SCHEMBL6510069 | 0.78 | HPGD (0.39) | ALDH1A1SMN1; SMN2HPGDPOLBMAPT | |
| SCHEMBL6510073 | 0.78 | HPGD (0.39) | ALDH1A1SMN1; SMN2HPGDPOLBMAPT | |
| SCHEMBL6513225 | 0.78 | HPGD (0.42) | ALDH1A1SMN1; SMN2HPGDPOLBMAPT | |
| SCHEMBL6514102 | 0.77 | HPGD (0.40) | ALDH1A1SMN1; SMN2HPGDPOLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005003103-A2 | 2, 4, 6-TRI-SUBSTITUTED 6-MEMBERED HETEROCYCLES AND THEIR USE IN THE TREATMENT OF NEURODEGENERATIVE DISEASES | ASTRAZENECA AB (SE) | 2005-01-13 | — | — | WO | claimed |
| WO-2005003103-A2 | 2, 4, 6-TRI-SUBSTITUTED 6-MEMBERED HETEROCYCLES AND THEIR USE IN THE TREATMENT OF NEURODEGENERATIVE DISEASES | ASTRAZENECA AB (SE) | 2005-01-13 | — | — | WO | disclosed |