Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 3/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.43 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.43 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.43 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3211253 | 0.86 | NPC1 (0.50) | ALDH1A1MEN1KMT2APOLBKCNH2 | |
| SCHEMBL5147271 | 0.84 | ALDH1A1 (0.46) | ALDH1A1MEN1KMT2APOLBKCNH2 | |
| SCHEMBL16519973 | 0.81 | TDP1 (0.48) | ALDH1A1MEN1KMT2ARAB9ANPC1 | |
| SCHEMBL5148269 | 0.81 | ALDH1A1 (0.45) | ALDH1A1MEN1KMT2ARAB9ANPC1 | |
| Bicarbonate SCHEMBL18955378 | 0.78 | ALDH1A1 (0.56) | ALDH1A1MEN1KMT2APOLBKCNH2 | |
| Bicarbonate SCHEMBL18955379 | 0.78 | ALDH1A1 (0.56) | ALDH1A1MEN1KMT2APOLBKCNH2 | |
| SCHEMBL57736 | 0.78 | ALDH1A1 (0.60) | ALDH1A1MEN1KMT2APOLBRAB9A | |
| SCHEMBL29911025 | 0.78 | ALDH1A1 (0.60) | ALDH1A1MEN1KMT2APOLBRAB9A | |
| SCHEMBL4686653 | 0.78 | TSHR (0.55) | ALDH1A1MEN1KMT2APOLBRAB9A | |
| SCHEMBL7628284 | 0.78 | KMT2A (0.48) | ALDH1A1MEN1KMT2APOLBRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050048552-A1 | Higher order structure and binding of peptide nucleic acids | ISIS PHARMACEUTICALS, INC. | 2005-03-03 | — | — | US | disclosed |
| US-6770738-B1 | USED TO MODULATE PROTEIN ACTIVITY THROUGH, FOR EXAMPLE, TRANSCRIPTION ARREST, TRANSCRIPTION INITIATION, AND SITE SPECIFIC CLEAVAGE OF NUCLEIC ACIDS | ISIS PHARMACEUTICALS, INC. | 2004-08-03 | — | — | US | disclosed |
| EP-0776331-B1 | HIGHER ORDER STRUCTURE AND BINDING OF PEPTIDE NUCLEIC ACIDS | ISIS PHARMACEUTICALS INC (US) | 2002-11-27 | — | — | EP | disclosed |
| US-5986053-A | NUCLEIC ACID COMPLEXES WITH MULTISTRANDS AND SEQUENCES | ISIS PHARMACEUTICALS, INC. (US) | 1999-11-16 | — | — | US | disclosed |
| US-5641625-A | PEPTIDE NUCLEIC ACIDS FORMING DUPLEX, TRIPLEX AND OTHER STRUCTURES WITH NUCLEIC ACIDS; MODULATION OF PROTEIN ACTIVITY BY TRANSCRIPTION ARREST AND INITIATION; SPECIFIC SITE CLEAVAGE | ISIS PHARMACEUTICALS, INC. (US) | 1997-06-24 | — | — | US | disclosed |
| EP-0776331-A1 | HIGHER ORDER STRUCTURE AND BINDING OF PEPTIDE NUCLEIC ACIDS | ISIS PHARMACEUTICALS, INC. (US) | 1997-06-04 | — | — | EP | disclosed |
| WO-1995001370-A1 | HIGHER ORDER STRUCTURE AND BINDING OF PEPTIDE NUCLEIC ACIDS | ISIS PHARMACEUTICALS, INC. (US) | 1995-01-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050048552-A1 | Higher order structure and binding of peptide nucleic acids | SSU72, DDX1, DDX18 | ALDH1A1 4852/4885MEN1 1868/4885KMT2A 2211/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.