Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC2A1 | P11166 | 2/20 | 0.42 |
| ▸ | NPR3 | P17342 | 3/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.41 |
| ▸ | SYK | P43405 | 1/20 | 0.40 |
| ▸ | SLK | Q9H2G2 | 3/20 | 0.39 |
| ▸ | STK10 | O94804 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | PTGES | O14684 | 3/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.37 |
| ▸ | PPARG | P37231 | 2/20 | 0.37 |
| ▸ | PPARA | Q07869 | 2/20 | 0.37 |
| ▸ | ELANE | P08246 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | RXRA | P19793 | 1/20 | 0.37 |
| ▸ | RXRG | P48443 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6513867 | 1.00 | SLC2A1 (0.42) | SLC2A1NPR3CYP2C9CYP2C19ABCG2 | |
| SCHEMBL6510872 | 0.86 | NPR3 (0.44) | SLC2A1NPR3CYP2C9CYP2C19ABCG2 | |
| SCHEMBL6510875 | 0.86 | NPR3 (0.44) | SLC2A1NPR3CYP2C9CYP2C19ABCG2 | |
| SCHEMBL6508232 | 0.77 | NPR3 (0.60) | NPR3CYP2C9CYP2C19ELANE | |
| SCHEMBL6508225 | 0.77 | NPR3 (0.60) | NPR3CYP2C9CYP2C19ELANE | |
| SCHEMBL6517243 | 0.76 | MAPT (0.43) | SLC2A1ABCG2SMN1; SMN2PTGESALOX5 | |
| SCHEMBL6530469 | 0.72 | NPR3 (0.55) | NPR3CYP2C9CYP2C19ELANE | |
| SCHEMBL6530463 | 0.72 | NPR3 (0.55) | NPR3CYP2C9CYP2C19ELANE | |
| SCHEMBL6507731 | 0.71 | CYP2C9 (0.43) | SLC2A1NPR3CYP2C9CYP2C19SMN1; SMN2 | |
| SCHEMBL6507727 | 0.71 | CYP2C9 (0.43) | SLC2A1NPR3CYP2C9CYP2C19SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005003103-A2 | 2, 4, 6-TRI-SUBSTITUTED 6-MEMBERED HETEROCYCLES AND THEIR USE IN THE TREATMENT OF NEURODEGENERATIVE DISEASES | ASTRAZENECA AB (SE) | 2005-01-13 | — | — | WO | disclosed |
| WO-2005003103-A2 | 2, 4, 6-TRI-SUBSTITUTED 6-MEMBERED HETEROCYCLES AND THEIR USE IN THE TREATMENT OF NEURODEGENERATIVE DISEASES | ASTRAZENECA AB (SE) | 2005-01-13 | — | — | WO | disclosed |