Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.42 |
| ▸ | PTGES | O14684 | 2/20 | 0.42 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.42 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.42 |
| ▸ | PPARG | P37231 | 5/20 | 0.41 |
| ▸ | PPARA | Q07869 | 5/20 | 0.41 |
| ▸ | RXRA | P19793 | 1/20 | 0.41 |
| ▸ | RXRG | P48443 | 1/20 | 0.41 |
| ▸ | PPARD | Q03181 | 1/20 | 0.41 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.41 |
| ▸ | PIM1 | P11309 | 1/20 | 0.41 |
| ▸ | PRKACA | P17612 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6510872 | 0.90 | NPR3 (0.44) | MAPTLMNAPOLBSLC2A1SMN1; SMN2 | |
| SCHEMBL6510875 | 0.90 | NPR3 (0.44) | MAPTLMNAPOLBSLC2A1SMN1; SMN2 | |
| SCHEMBL6510400 | 0.80 | HPGD (0.44) | LMNAPOLB | |
| SCHEMBL6512174 | 0.79 | CTSK (0.40) | MAPTLMNAPOLBSLC2A1SMN1; SMN2 | |
| SCHEMBL6512168 | 0.79 | CTSK (0.40) | MAPTLMNAPOLBSLC2A1SMN1; SMN2 | |
| SCHEMBL6513858 | 0.76 | SLC2A1 (0.42) | MAPTSLC2A1SMN1; SMN2ALOX5PTGES | |
| SCHEMBL6513867 | 0.76 | SLC2A1 (0.42) | MAPTSLC2A1SMN1; SMN2ALOX5PTGES | |
| SCHEMBL6530463 | 0.76 | NPR3 (0.55) | POLBCNR2 | |
| SCHEMBL6530469 | 0.76 | NPR3 (0.55) | POLBCNR2 | |
| SCHEMBL6507727 | 0.75 | CYP2C9 (0.43) | MAPTLMNAPOLBSLC2A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005003103-A2 | 2, 4, 6-TRI-SUBSTITUTED 6-MEMBERED HETEROCYCLES AND THEIR USE IN THE TREATMENT OF NEURODEGENERATIVE DISEASES | ASTRAZENECA AB (SE) | 2005-01-13 | — | — | WO | disclosed |