Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | IDO1 | P14902 | 1/20 | 0.52 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | CTSS | P25774 | 1/20 | 0.45 |
| ▸ | PPARA | Q07869 | 1/20 | 0.45 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6514567 | 1.00 | SYK (0.56) | SYKL3MBTL1IDO1NTSR1MAPT | |
| Hydrochloric Acid SCHEMBL6512895 | 0.99 | SYK (0.55) | SYKL3MBTL1IDO1NTSR1MAPT | |
| Hydrochloric Acid SCHEMBL6512903 | 0.99 | SYK (0.55) | SYKL3MBTL1IDO1NTSR1MAPT | |
| SCHEMBL22987362 | 0.90 | LMNA (0.53) | SYKL3MBTL1IDO1MAPTPOLB | |
| SCHEMBL15202883 | 0.85 | SYK (0.64) | SYKL3MBTL1IDO1MAPTLMNA | |
| SCHEMBL6045085 | 0.84 | SYK (0.53) | SYKL3MBTL1IDO1MAPTMAPK1 | |
| SCHEMBL2134843 | 0.84 | POLB (0.49) | SYKL3MBTL1NTSR1MAPTTDP1 | |
| SCHEMBL2134853 | 0.84 | POLB (0.49) | SYKL3MBTL1NTSR1MAPTTDP1 | |
| SCHEMBL2137272 | 0.84 | POLB (0.49) | SYKL3MBTL1NTSR1MAPTTDP1 | |
| SCHEMBL30387033 | 0.83 | SYK (0.63) | SYKL3MBTL1IDO1MAPTCTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050048552-A1 | Higher order structure and binding of peptide nucleic acids | ISIS PHARMACEUTICALS, INC. | 2005-03-03 | — | — | US | disclosed |
| US-6770738-B1 | USED TO MODULATE PROTEIN ACTIVITY THROUGH, FOR EXAMPLE, TRANSCRIPTION ARREST, TRANSCRIPTION INITIATION, AND SITE SPECIFIC CLEAVAGE OF NUCLEIC ACIDS | ISIS PHARMACEUTICALS, INC. | 2004-08-03 | — | — | US | disclosed |
| EP-0776331-B1 | HIGHER ORDER STRUCTURE AND BINDING OF PEPTIDE NUCLEIC ACIDS | ISIS PHARMACEUTICALS INC (US) | 2002-11-27 | — | — | EP | disclosed |
| US-5986053-A | NUCLEIC ACID COMPLEXES WITH MULTISTRANDS AND SEQUENCES | ISIS PHARMACEUTICALS, INC. (US) | 1999-11-16 | — | — | US | disclosed |
| US-5641625-A | PEPTIDE NUCLEIC ACIDS FORMING DUPLEX, TRIPLEX AND OTHER STRUCTURES WITH NUCLEIC ACIDS; MODULATION OF PROTEIN ACTIVITY BY TRANSCRIPTION ARREST AND INITIATION; SPECIFIC SITE CLEAVAGE | ISIS PHARMACEUTICALS, INC. (US) | 1997-06-24 | — | — | US | disclosed |
| EP-0776331-A1 | HIGHER ORDER STRUCTURE AND BINDING OF PEPTIDE NUCLEIC ACIDS | ISIS PHARMACEUTICALS, INC. (US) | 1997-06-04 | — | — | EP | disclosed |
| WO-1995001370-A1 | HIGHER ORDER STRUCTURE AND BINDING OF PEPTIDE NUCLEIC ACIDS | ISIS PHARMACEUTICALS, INC. (US) | 1995-01-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050048552-A1 | Higher order structure and binding of peptide nucleic acids | SSU72, DDX1, DDX18 | SYK 4191/4885L3MBTL1 385/4885IDO1 4735/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.