Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 5/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 6/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | IKBKB | O14920 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6505484 | 0.81 | CHEK1 (0.55) | CHEK1MEN1KMT2AIKBKBALDH1A1 | |
| SCHEMBL6511724 | 0.80 | MAPT (0.51) | CHEK1RAB9ANPC1ATMMEN1 | |
| SCHEMBL20764440 | 0.75 | MEN1 (0.67) | RAB9ANPC1ATMMEN1KMT2A | |
| SCHEMBL6506758 | 0.74 | IKBKB (0.50) | CHEK1RAB9ANPC1MEN1KMT2A | |
| SCHEMBL6505865 | 0.74 | IKBKB (0.58) | CHEK1MEN1KMT2AIKBKBJAK2 | |
| SCHEMBL6507152 | 0.73 | IKBKB (0.57) | CHEK1MEN1KMT2AIKBKBALDH1A1 | |
| SCHEMBL6507704 | 0.72 | CHEK1 (0.49) | CHEK1RAB9ANPC1MEN1KMT2A | |
| SCHEMBL21446740 | 0.71 | HDAC1 (0.58) | RAB9ANPC1MEN1KMT2ARXFP1 | |
| SCHEMBL2406105 | 0.71 | NPC1 (0.52) | RAB9ANPC1ATMMEN1KMT2A | |
| SCHEMBL6243177 | 0.70 | NPC1 (0.72) | RAB9ANPC1ATMMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005105777-A1 | SUBSTITUTED THIOPHENE AMIDE COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | PHARMACIA & UPJOHN COMPANY LLC (US) | 2005-11-10 | — | — | WO | disclosed |