Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 7/20 | 0.41 |
| ▸ | MAPK13 | O15264 | 3/20 | 0.41 |
| ▸ | MAPK12 | P53778 | 3/20 | 0.41 |
| ▸ | MAPK11 | Q15759 | 3/20 | 0.41 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.36 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.35 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.34 |
| ▸ | CDK1 | P06493 | 1/20 | 0.34 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.34 |
| ▸ | GSK3A | P49840 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.34 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.34 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.34 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.34 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2295783 | 0.83 | MAPK14 (0.41) | MAPK14MAPK13MAPK12MAPK11IDO1 | |
| SCHEMBL4097997 | 0.70 | MAPK14 (0.68) | MAPK14MAPK13MAPK12MAPK11IDO1 | |
| SCHEMBL6508399 | 0.69 | MEN1 (0.38) | MAPK14MAPK13MAPK12MAPK11MAPKAPK2 | |
| SCHEMBL22068158 | 0.66 | IDO1 (0.55) | MAPK14MAPK13MAPK12MAPK11IDO1 | |
| SCHEMBL8836231 | 0.65 | TDO2 (0.45) | MAPK14MAPK13MAPK12MAPK11IDO1 | |
| SCHEMBL2299116 | 0.64 | MAPK14 (0.42) | MAPK14MAPK13MAPK12MAPK11MAPT | |
| SCHEMBL828544 | 0.64 | MAPK14 (0.55) | MAPK14MAPK13MAPK12MAPK11IDO1 | |
| SCHEMBL6984697 | 0.63 | MAPK14 (0.69) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL21067592 | 0.63 | MAPK14 (0.47) | MAPK14MAPK13MAPK12MAPK11IDO1 | |
| SCHEMBL28480049 | 0.62 | ESR2 (0.48) | IDO1MAPTCDK5CDK5R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005105814-A1 | TETRACYCLIC INHIBITORS OF JANUS KINASES | INCYTE CORPORATION (US) | 2005-11-10 | — | — | WO | disclosed |