Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 16/20 | 0.42 |
| ▸ | GCGR | P47871 | 5/20 | 0.41 |
| ▸ | MAPK13 | O15264 | 4/20 | 0.40 |
| ▸ | MAPK12 | P53778 | 4/20 | 0.40 |
| ▸ | MAPK11 | Q15759 | 4/20 | 0.40 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.40 |
| ▸ | RAF1 | P04049 | 2/20 | 0.40 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.39 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.39 |
| ▸ | FRK | P42685 | 2/20 | 0.39 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.39 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.39 |
| ▸ | GSK3B | P49841 | 2/20 | 0.39 |
| ▸ | PTK6 | Q13882 | 2/20 | 0.39 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.39 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | CIT | O14578 | 1/20 | 0.38 |
| ▸ | GAK | O14976 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2295783 | 0.82 | MAPK14 (0.41) | MAPK14MAPK13MAPK12MAPK11MAPK10 | |
| SCHEMBL6508399 | 0.80 | MEN1 (0.38) | MAPK14GCGRMAPK13MAPK12MAPK11 | |
| SCHEMBL464630 | 0.70 | LMNA (0.65) | MAPK14GCGRMAPK13MAPK12MAPK11 | |
| SCHEMBL6829472 | 0.70 | LMNA (0.65) | MAPK14GCGRMAPK13MAPK12MAPK11 | |
| SCHEMBL6112627 | 0.70 | MAPK14 (0.55) | MAPK14GCGRMAPK13MAPK12MAPK11 | |
| SCHEMBL1150867 | 0.67 | MAPK14 (0.68) | MAPK14GCGRMAPK13MAPK12MAPK11 | |
| SCHEMBL4285503 | 0.65 | MAPK14 (0.48) | MAPK14GCGRMAPK13MAPK12MAPK11 | |
| SCHEMBL6515232 | 0.64 | MAPK14 (0.41) | MAPK14MAPK13MAPK12MAPK11GSK3B | |
| SCHEMBL1230814 | 0.62 | MAPK14 (0.47) | MAPK14GCGRMAPK13MAPK12MAPK11 | |
| SCHEMBL6337863 | 0.61 | MAPK14 (0.60) | MAPK14GCGRMAPK13MAPK12MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011100769-A2 | KINASE MODULATORS FOR THE TREATMENT OF CANCER | SYNOVO GMBH (DE) | 2011-08-18 | — | — | WO | disclosed |