Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
| ▸ | TEK | Q02763 | 3/20 | 0.35 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.33 |
| ▸ | BCHE | P06276 | 2/20 | 0.33 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
| ▸ | ITK | Q08881 | 1/20 | 0.32 |
| ▸ | HTR6 | P50406 | 1/20 | 0.32 |
| ▸ | PDE5A | O76074 | 1/20 | 0.31 |
| ▸ | OXTR | P30559 | 3/20 | 0.31 |
| ▸ | AVPR1A | P37288 | 3/20 | 0.31 |
| ▸ | AVPR1B | P47901 | 3/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | CRHBP | P24387 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL651698 | 0.91 | NPC1 (0.36) | PDE4BTEKSLC2A1BCHECNR2 | |
| SCHEMBL648105 | 0.85 | C5AR1 (0.38) | BCHEC5AR1CNR2AVPR1BMEN1 | |
| SCHEMBL650630 | 0.83 | MKNK1 (0.36) | ITKMEN1ALDH1A1LMNAMAPT | |
| SCHEMBL5137557 | 0.83 | C5AR1 (0.42) | BCHEC5AR1MEN1ALDH1A1LMNA | |
| SCHEMBL14099616 | 0.82 | ALOX5 (0.34) | PDE4BBCHEC5AR1CNR2HTR6 | |
| SCHEMBL4766337 | 0.82 | C5AR1 (0.38) | BCHEC5AR1CNR2MEN1ALDH1A1 | |
| SCHEMBL651696 | 0.81 | PDE4B (0.36) | PDE4BTEKPDE5AOXTRAVPR1A | |
| SCHEMBL5137356 | 0.79 | MEN1 (0.45) | PDE4BC5AR1CNR2MEN1ALDH1A1 | |
| SCHEMBL648304 | 0.79 | C5AR1 (0.41) | BCHEC5AR1MEN1ALDH1A1KMT2A | |
| SCHEMBL5225249 | 0.78 | C5AR1 (0.38) | BCHEC5AR1CNR2AVPR1BMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8119665-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD. (BM) | 2012-02-21 | — | — | US | disclosed |