Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
| ▸ | TEK | Q02763 | 4/20 | 0.34 |
| ▸ | LMNA | P02545 | 3/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | CRHBP | P24387 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | CNR1 | P21554 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | AVPR1B | P47901 | 4/20 | 0.31 |
| ▸ | OXTR | P30559 | 1/20 | 0.31 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.31 |
| ▸ | CCR5 | P51681 | 2/20 | 0.31 |
| ▸ | PDE5A | O76074 | 1/20 | 0.31 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL651697 | 0.81 | PDE4B (0.37) | PDE4BTEKLMNAMAPTALDH1A1 | |
| SCHEMBL4769324 | 0.78 | C5AR1 (0.39) | MAPTALDH1A1NPSR1TP53MDM2 | |
| SCHEMBL649268 | 0.75 | ALDH1A1 (0.33) | LMNAMAPTALDH1A1MEN1CRHBP | |
| SCHEMBL4764000 | 0.72 | ALDH1A1 (0.42) | PDE4BMAPTALDH1A1MEN1KMT2A | |
| SCHEMBL651698 | 0.72 | NPC1 (0.36) | PDE4BTEKLMNAMAPTALDH1A1 | |
| SCHEMBL648736 | 0.71 | ATM (0.36) | LMNAMAPTALDH1A1MEN1KMT2A | |
| SCHEMBL648898 | 0.70 | LMNA (0.36) | LMNAMAPTALDH1A1MEN1KMT2A | |
| SCHEMBL651425 | 0.69 | MTNR1B (0.35) | MAPTALDH1A1MEN1KMT2A | |
| SCHEMBL10289127 | 0.68 | BCHE (0.41) | PDE4BLMNAALDH1A1MEN1KMT2A | |
| SCHEMBL651079 | 0.68 | AGTR1 (0.34) | LMNAALDH1A1MDM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8119665-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD. (BM) | 2012-02-21 | — | — | US | disclosed |