Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.71 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.71 |
| ▸ | HTT | P42858 | 1/20 | 0.71 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.54 |
| ▸ | VCAM1 | P19320 | 7/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | POLB | P06746 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 6/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10060156 | 0.83 | ALDH1A1 (0.71) | ALDH1A1KDM4EHTTHCAR3VCAM1 | |
| SCHEMBL17845547 | 0.83 | ALDH1A1 (0.51) | ALDH1A1KDM4EHTTHCAR3VCAM1 | |
| SCHEMBL17845544 | 0.83 | ALDH1A1 (0.51) | ALDH1A1KDM4EHTTHCAR3VCAM1 | |
| SCHEMBL3813276 | 0.78 | VCAM1 (0.50) | ALDH1A1KDM4EHTTVCAM1KMT2A | |
| SCHEMBL274368 | 0.77 | MCOLN3 (0.56) | ALDH1A1KDM4EHTTKMT2APOLB | |
| SCHEMBL6816481 | 0.77 | ALDH1A1 (0.58) | ALDH1A1KDM4EHTTHCAR3VCAM1 | |
| SCHEMBL30610948 | 0.77 | ALDH1A1 (0.58) | ALDH1A1KDM4EHTTHCAR3VCAM1 | |
| SCHEMBL30430459 | 0.77 | MCOLN3 (0.56) | ALDH1A1KDM4EHTTKMT2APOLB | |
| SCHEMBL17863601 | 0.77 | ALDH1A1 (0.45) | ALDH1A1KDM4EHTTHCAR3VCAM1 | |
| SCHEMBL31122066 | 0.77 | ALDH1A1 (0.45) | ALDH1A1KDM4EHTTHCAR3VCAM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1051655-B1 | METHODS AND APPARATUS FOR ACCELERATED ORTHOKERATOLOGY | ISTA PHARMACEUTICALS INC (US) | 2005-09-28 | — | — | EP | disclosed |
| EP-1051655-A4 | METHODS AND APPARATUS FOR ACCELERATED ORTHOKERATOLOGY | ISTA PHARMACEUTICALS INC (US) | 2003-03-19 | — | — | EP | disclosed |
| US-20010016731-A1 | Methods and apparatus for accelerated orthokeratology | DEVORE DALE (US) | 2001-08-23 | — | — | US | disclosed |
| CN-1295677-A | Method and apparatus for accelerated orthokeratology | EASTA PHARMACEUTICALS INC (US) | 2001-05-16 | — | — | CN | disclosed |
| US-6161544-A | Methods for accelerated orthokeratology | KERATOFORM, INC. (US) | 2000-12-19 | — | — | US | disclosed |
| EP-1051655-A1 | METHODS AND APPARATUS FOR ACCELERATED ORTHOKERATOLOGY | Ista Pharmaceuticals, Inc. (US) | 2000-11-15 | — | — | EP | disclosed |
| WO-1999039238-A1 | METHODS AND APPARATUS FOR ACCELERATED ORTHOKERATOLOGY | KERATOFORM, INC. (US) | 1999-08-05 | — | — | WO | disclosed |