Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 3/20 | 0.80 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.64 |
| ▸ | RAB9A | P51151 | 4/20 | 0.64 |
| ▸ | MEN1 | O00255 | 3/20 | 0.64 |
| ▸ | POLB | P06746 | 2/20 | 0.64 |
| ▸ | LMNA | P02545 | 2/20 | 0.64 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.64 |
| ▸ | CRHBP | P24387 | 5/20 | 0.59 |
| ▸ | CRHR2 | Q13324 | 5/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.59 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.58 |
| ▸ | RAD52 | P43351 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10498926 | 0.79 | CRHBP (0.83) | MAPK1KMT2ARAB9AMEN1POLB | |
| SCHEMBL5923408 | 0.78 | MAPK1 (0.50) | MAPK1RAB9ASIRT2ALDH1A1 | |
| SCHEMBL6510821 | 0.77 | CRHBP (0.80) | MAPK1KMT2ARAB9AMEN1POLB | |
| SCHEMBL3426124 | 0.75 | SIRT2 (0.59) | KMT2ARAB9APOLBCYP1A2SIRT2 | |
| SCHEMBL27803805 | 0.73 | SIRT2 (0.52) | MAPK1RAB9APOLBLMNASMN1; SMN2 | |
| SCHEMBL11128203 | 0.72 | RAB9A (0.59) | MAPK1KMT2ARAB9AMEN1LMNA | |
| SCHEMBL6513368 | 0.71 | CRHBP (1.00) | MAPK1KMT2ARAB9AMEN1POLB | |
| SCHEMBL10388189 | 0.71 | KMT2A (0.66) | MAPK1KMT2ARAB9AMEN1POLB | |
| SCHEMBL11159873 | 0.71 | MAPT (0.60) | MAPK1KMT2ARAB9AMEN1POLB | |
| SCHEMBL4981988 | 0.71 | MAPK1 (0.69) | MAPK1KMT2ARAB9AMEN1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005095345-A2 | HETEROARYL GUANIDINES AS INHIBITORS OF VIRAL REPLICATION | ACHILLION PHARMACEUTICALS, INC. (US) | 2005-10-13 | — | — | WO | claimed |