Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | ELANE | P08246 | 4/20 | 0.39 |
| ▸ | TAS1R3 | Q7RTX0 | 4/20 | 0.38 |
| ▸ | TAS1R1 | Q7RTX1 | 4/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | NPR3 | P17342 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6517775 | 1.00 | MAPT (0.40) | MAPTHTTELANETAS1R3TAS1R1 | |
| SCHEMBL8297667 | 0.77 | TAS1R3 (0.38) | ELANETAS1R3TAS1R1KDM4EALDH1A1 | |
| SCHEMBL6509030 | 0.76 | TAS1R3 (0.46) | ELANETAS1R3TAS1R1CYP2C9NPR3 | |
| SCHEMBL6509026 | 0.76 | TAS1R3 (0.46) | ELANETAS1R3TAS1R1CYP2C9NPR3 | |
| SCHEMBL6512154 | 0.73 | TAS1R3 (0.43) | ELANETAS1R3TAS1R1 | |
| SCHEMBL6512159 | 0.73 | TAS1R3 (0.43) | ELANETAS1R3TAS1R1 | |
| SCHEMBL8964493 | 0.72 | TAS1R3 (0.65) | TAS1R3TAS1R1KDM4EALDH1A1POLB | |
| SCHEMBL8964497 | 0.72 | TAS1R3 (0.65) | TAS1R3TAS1R1KDM4EALDH1A1POLB | |
| SCHEMBL6508736 | 0.70 | NPR3 (0.53) | ELANETAS1R3TAS1R1CYP2C9NPR3 | |
| SCHEMBL6508740 | 0.70 | NPR3 (0.53) | ELANETAS1R3TAS1R1CYP2C9NPR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005003103-A2 | 2, 4, 6-TRI-SUBSTITUTED 6-MEMBERED HETEROCYCLES AND THEIR USE IN THE TREATMENT OF NEURODEGENERATIVE DISEASES | ASTRAZENECA AB (SE) | 2005-01-13 | — | — | WO | disclosed |
| WO-2005003103-A2 | 2, 4, 6-TRI-SUBSTITUTED 6-MEMBERED HETEROCYCLES AND THEIR USE IN THE TREATMENT OF NEURODEGENERATIVE DISEASES | ASTRAZENECA AB (SE) | 2005-01-13 | — | — | WO | disclosed |