Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS1R3 | Q7RTX0 | 7/20 | 0.43 |
| ▸ | TAS1R1 | Q7RTX1 | 7/20 | 0.43 |
| ▸ | ANPEP | P15144 | 2/20 | 0.39 |
| ▸ | ELANE | P08246 | 5/20 | 0.38 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.36 |
| ▸ | MMP1 | P03956 | 1/20 | 0.36 |
| ▸ | MMP3 | P08254 | 1/20 | 0.36 |
| ▸ | MMP9 | P14780 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6512159 | 1.00 | TAS1R3 (0.43) | TAS1R3TAS1R1ANPEPELANEADAM17 | |
| SCHEMBL6515278 | 0.84 | TAS1R3 (0.42) | TAS1R3TAS1R1ANPEPELANEADAM17 | |
| SCHEMBL6515272 | 0.84 | TAS1R3 (0.42) | TAS1R3TAS1R1ANPEPELANEADAM17 | |
| SCHEMBL8297653 | 0.82 | TAS1R3 (0.43) | TAS1R3TAS1R1ANPEPELANE | |
| SCHEMBL6509874 | 0.81 | TAS1R3 (0.44) | TAS1R3TAS1R1ANPEPADAM17MMP1 | |
| SCHEMBL6509886 | 0.81 | TAS1R3 (0.44) | TAS1R3TAS1R1ANPEPADAM17MMP1 | |
| SCHEMBL6510461 | 0.80 | ALDH1A1 (0.40) | TAS1R3TAS1R1 | |
| SCHEMBL6510466 | 0.80 | ALDH1A1 (0.40) | TAS1R3TAS1R1 | |
| SCHEMBL6511358 | 0.76 | NPR3 (0.45) | TAS1R3TAS1R1ANPEPELANE | |
| SCHEMBL6511364 | 0.76 | NPR3 (0.45) | TAS1R3TAS1R1ANPEPELANE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005003103-A2 | 2, 4, 6-TRI-SUBSTITUTED 6-MEMBERED HETEROCYCLES AND THEIR USE IN THE TREATMENT OF NEURODEGENERATIVE DISEASES | ASTRAZENECA AB (SE) | 2005-01-13 | — | — | WO | disclosed |
| WO-2005003103-A2 | 2, 4, 6-TRI-SUBSTITUTED 6-MEMBERED HETEROCYCLES AND THEIR USE IN THE TREATMENT OF NEURODEGENERATIVE DISEASES | ASTRAZENECA AB (SE) | 2005-01-13 | — | — | WO | disclosed |