Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.33 |
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.33 |
| ▸ | CHRM3 known ✓ | P20309 | 1/20 | 0.33 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.33 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 2/20 | 0.35 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.33 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | HRH1 | P35367 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6516976 | 0.80 | HTR2A (0.33) | HTR2ATP53HSD17B10MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL6514173 | 0.77 | DRD2 (0.36) | CYP11B1CYP11B2DRD2 | |
| Hydrochloric Acid SCHEMBL6520707 | 0.77 | DRD2 (0.36) | CYP11B1CYP11B2DRD2 | |
| SCHEMBL4660518 | 0.74 | HTR2A (0.39) | HTR2ACYP11B1CYP11B2KDM4ELMNA | |
| Hydrochloric Acid SCHEMBL27948828 | 0.73 | HTR2A (0.38) | HTR2ACYP11B1CYP11B2KDM4ELMNA | |
| Hydrochloric Acid SCHEMBL28806996 | 0.73 | HTR2A (0.38) | HTR2ACYP11B1CYP11B2KDM4ELMNA | |
| Hydrochloric Acid SCHEMBL27932976 | 0.73 | HTR2A (0.38) | HTR2ACYP11B1CYP11B2KDM4ELMNA | |
| Hydrochloric Acid SCHEMBL28073396 | 0.73 | CYP11B1 (0.40) | HTR2ACYP11B1CYP11B2KDM4ELMNA | |
| Hydrochloric Acid SCHEMBL6521388 | 0.72 | CYP19A1 (0.31) | CYP11B1CYP11B2 | |
| Hydrochloric Acid SCHEMBL6514685 | 0.72 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6872863-B2 | Methylene bridged metallocenes as olefin-polymerization catalyst components | BASELL POLYOLEFINE GMBH (DE) | 2005-03-29 | — | — | US | disclosed |
| US-20040147695-A1 | Methylene bridged metallocenes as olefin-polymerization catalyst components | BASELL POLIOLEFINE ITALIA S.P.A. (IT) | 2004-07-29 | — | — | US | disclosed |
| US-6693156-B1 | SIMPLY AND EFFICIENTLY SYNTHESIZED MATERIALS WITH VARIED SUBSTITUTION FOR TAILORED POLYMER PROPERTIES | BASELL POLYOLEFINE GMBH (DE) | 2004-02-17 | — | — | US | disclosed |
| EP-1131328-B1 | METHYLENE BRIDGED METALLOCENES AS OLEFIN-POLYMERIZATION-CATALYST COMPONENTS | BASELL POLYOLEFINE GMBH (DE) | 2003-05-07 | — | — | EP | disclosed |
| EP-1131328-A1 | METHYLENE BRIDGED METALLOCENES AS OLEFIN-POLYMERIZATION-CATALYST COMPONENTS | Basell Technology Company B.V. (NL) | 2001-09-12 | — | — | EP | disclosed |
| WO-2000029415-A1 | METHYLENE BRIDGED METALLOCENES AS OLEFIN-POLYMERIZATION-CATALYST COMPONENTS | BASELL TECHNOLOGY COMPANY B.V. (NL) | 2000-05-25 | — | — | WO | disclosed |