Sugi Predict

Sugi Predict / Compounds / SCHEMBL6519482

SCHEMBL6519482

SCHEMBL6519482

O=c1[nH]c2nccc(Nc3c(Cl)ccc4c3OCO4)c2c2ccc(OCCN3CCOCC3)cc12

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ SRC P12931 12/20 0.57
▸ KDR P35968 8/20 0.57
▸ EPHB4 P54760 4/20 0.47
▸ CSK P41240 3/20 0.47
▸ EGFR P00533 2/20 0.47
▸ LCK P06239 2/20 0.47
▸ YES1 P07947 2/20 0.47
▸ PKMYT1 Q99640 2/20 0.47
▸ BMPR1B O00238 1/20 0.47
▸ GAK O14976 1/20 0.47
▸ EPHB6 O15197 1/20 0.47
▸ RIPK2 O43353 1/20 0.47
▸ STK10 O94804 1/20 0.47
▸ MAP4K4 O95819 1/20 0.47
▸ ABL1 P00519 1/20 0.47
▸ FYN P06241 1/20 0.47
▸ LYN P07948 1/20 0.47
▸ RET P07949 1/20 0.47
▸ HCK P08631 1/20 0.47
▸ PDGFRB P09619 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6523005 0.82 MAOA (0.53) KDRPDGFRBFGFR1AURKBKDM4E
SCHEMBL6521071 0.78 SIGMAR1 (0.54) AURKBKDM4EALDH1A1MAOAPARP1
SCHEMBL6517743 0.78 AURKA (0.53) EPHB4AURKB
SCHEMBL6523245 0.77 EPHB4 (0.51) SRCKDREPHB4CSKTEK
SCHEMBL2488151 0.71 AURKA (0.52) EPHB4
SCHEMBL6519489 0.70 KDM4E (0.41) KDRPDGFRBFLT3FGFR1AURKB
SCHEMBL681260 0.69 ACVRL1 (0.48) EPHB4
SCHEMBL2285744 0.69 SRC (0.62) SRCKDREPHB4CSKEGFR
SCHEMBL18395398 0.68 SRC (0.69) SRCKDREPHB4CSKEGFR
SCHEMBL3276936 0.67 SRC (1.00) SRCKDREPHB4CSKEGFR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8735584-B2 Protein kinase inhibitors and use thereof MERCK PATENT GMBH (DE) 2014-05-27 — — US disclosed
US-8735584-B2 Protein kinase inhibitors and use thereof MERCK PATENT GMBH (DE) 2014-05-27 — — US disclosed
US-8735584-B2 Protein kinase inhibitors and use thereof MERCK PATENT GMBH (DE) 2014-05-27 — — US disclosed
EP-2254889-B1 PROTEIN KINASE INHIBITORS AND USE THEREOF MERCK PATENT GMBH (DE) 2012-12-19 — — EP disclosed
EP-2254889-B1 PROTEIN KINASE INHIBITORS AND USE THEREOF MERCK PATENT GMBH (DE) 2012-12-19 — — EP disclosed
US-20110053906-A1 PROTEIN KINASE INHIBITORS AND USE THEREOF MERCK PATENT GMBH (DE) 2011-03-03 — — US disclosed
US-20110053906-A1 PROTEIN KINASE INHIBITORS AND USE THEREOF MERCK PATENT GMBH (DE) 2011-03-03 — — US disclosed
US-20110053906-A1 PROTEIN KINASE INHIBITORS AND USE THEREOF MERCK PATENT GMBH (DE) 2011-03-03 — — US disclosed
WO-2009108670-A1 PROTEIN KINASE INHIBITORS AND USE THEREOF MERCK SERONO S.A. (CH) 2009-09-03 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110053906-A1 PROTEIN KINASE INHIBITORS AND USE THEREOF MAP4K2, MAP3K20, MAP4K1 SRC 193/4885KDR 1368/4885EPHB4 2587/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.