SCHEMBL6521897

SCHEMBL6521897

Cc1oncc1N1CCC(=Cc2cccc(OCCc3cccc(F)c3)c2)CC1

nearest known ligand 0.37

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
F10 P00742 1/20 0.37
MAOA P21397 2/20 0.37
MAOB P27338 2/20 0.37
GPR55 Q9Y2T6 1/20 0.36
OGA O60502 1/20 0.35
NR1H4 Q96RI1 2/20 0.34
HTR6 P50406 1/20 0.34
SIRT2 Q8IXJ6 1/20 0.33
ACHE P22303 1/20 0.33
AKR1B1 P15121 1/20 0.33
PTPN1 P18031 1/20 0.33
HTR1A P08908 1/20 0.33
PPARG P37231 1/20 0.32
PPARA Q07869 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6521424 0.93 GPR55 (0.37) F10MAOAMAOBGPR55OGA
SCHEMBL6525256 0.83 OGA (0.36) MAOBGPR55OGA
SCHEMBL6525594 0.82 F10 (0.37) F10MAOAMAOBGPR55OGA
SCHEMBL1036881 0.82 CYP3A4 (0.44) F10MAOAMAOBOGASIRT2
SCHEMBL6522876 0.82 HPGD (0.40) GPR55OGAHTR1A
SCHEMBL6518914 0.78 OGA (0.36) OGANR1H4
SCHEMBL6520518 0.77 OGA (0.35) OGA
SCHEMBL1037030 0.76 FAAH (0.47) F10OGASIRT2
SCHEMBL6516046 0.75 HPGD (0.37) OGA
SCHEMBL1034921 0.75 CYP3A4 (0.47) F10MAOBGPR55OGANR1H4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20110053982-A1 ETHER BENZYLIDENE PIPERIDINE 5-MEMBERED ARYL CARBOXAMIDE COMPOUNDS USEFUL AS FAAH INHIBITORS PFIZER INC. (US) 2011-03-03 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110053982-A1 ETHER BENZYLIDENE PIPERIDINE 5-MEMBERED ARYL CARBOXAMIDE COMPOUNDS USEFUL AS FAAH INHIBITORS FAAH, FAAH2, CNR2 F10 2079/4885MAOA 147/4885MAOB 149/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.