Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 2/20 | 0.49 |
| ▸ | PTGS2 | P35354 | 5/20 | 0.48 |
| ▸ | ALOX5 | P09917 | 5/20 | 0.48 |
| ▸ | ELANE | P08246 | 2/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6520800 | 0.95 | ALOX5 (0.43) | PPARAPTGS2ALOX5ELANE | |
| SCHEMBL6523352 | 0.86 | C5AR1 (0.38) | PPARAPTGS2ALOX5 | |
| SCHEMBL1328874 | 0.84 | BCHE (0.48) | — | |
| SCHEMBL1327003 | 0.81 | C5AR1 (0.48) | — | |
| SCHEMBL6522026 | 0.81 | S1PR1 (0.41) | PPARAPTGS2ALOX5 | |
| SCHEMBL6518976 | 0.81 | GABRA1 (0.40) | — | |
| SCHEMBL1328280 | 0.80 | FFAR1 (0.41) | — | |
| SCHEMBL1328287 | 0.80 | BCHE (0.56) | — | |
| SCHEMBL1329405 | 0.80 | BCHE (0.56) | — | |
| SCHEMBL6522088 | 0.80 | NPSR1 (0.36) | PTGS2ELANE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1565452-A2 | 3-SUBSTITUTED-6-ARYL PYRIDINES AS LIGANDS OF C5A RECEPTORS | NEUROGEN CORPORATION (US) | 2005-08-24 | — | — | EP | disclosed |
| WO-2004043925-A2 | 3-SUBSTITUTED-6-ARYL PYRIDINED AS LIGANDS OF C5A RECEPTORS | NEUROGEN CORPORATION (US) | 2004-05-27 | — | — | WO | disclosed |