Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | C5AR1 | P21730 | 4/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | MITF | O75030 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | GLS | O94925 | 2/20 | 0.34 |
| ▸ | ELANE | P08246 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.31 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.31 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6518505 | 0.89 | C5AR1 (0.37) | NPSR1MAPTL3MBTL1C5AR1GLS | |
| SCHEMBL6515324 | 0.85 | MAPT (0.41) | NPSR1MAPTL3MBTL1KDM4EMAPK1 | |
| SCHEMBL6522038 | 0.83 | C5AR1 (0.33) | NPSR1MAPTL3MBTL1C5AR1 | |
| SCHEMBL1328160 | 0.81 | C5AR1 (0.41) | NPSR1MAPTL3MBTL1C5AR1ELANE | |
| SCHEMBL6515014 | 0.80 | MAPK1 (0.40) | L3MBTL1MAPK1POLB | |
| SCHEMBL6522043 | 0.80 | PPARA (0.49) | ELANEPTGS2 | |
| SCHEMBL6523352 | 0.79 | C5AR1 (0.38) | L3MBTL1C5AR1PTGS2 | |
| SCHEMBL6520800 | 0.79 | ALOX5 (0.43) | C5AR1ELANEPTGS2 | |
| SCHEMBL6516516 | 0.78 | ALDH1A1 (0.41) | THRBALDH1A1POLB | |
| SCHEMBL6522026 | 0.76 | S1PR1 (0.41) | C5AR1PTGS2SLC6A2SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1565452-A2 | 3-SUBSTITUTED-6-ARYL PYRIDINES AS LIGANDS OF C5A RECEPTORS | NEUROGEN CORPORATION (US) | 2005-08-24 | — | — | EP | disclosed |
| WO-2004043925-A2 | 3-SUBSTITUTED-6-ARYL PYRIDINED AS LIGANDS OF C5A RECEPTORS | NEUROGEN CORPORATION (US) | 2004-05-27 | — | — | WO | disclosed |