SCHEMBL6522331

SCHEMBL6522331

O=Cc1cccc(COCc2ccccc2)c1

nearest known ligand 0.65

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOA P21397 7/20 0.65
MAOB P27338 7/20 0.65
TSHR P16473 1/20 0.56
ALDH1A1 P00352 4/20 0.46
CYP2A6 P11509 1/20 0.46
RAB9A P51151 3/20 0.46
NPC1 O15118 2/20 0.46
CCNB2 O95067 1/20 0.46
CDK1 P06493 1/20 0.46
CDK4 P11802 1/20 0.46
CCNB1 P14635 1/20 0.46
CCND1 P24385 1/20 0.46
CCNB3 Q8WWL7 1/20 0.46
TDP1 Q9NUW8 1/20 0.46
KDM4E B2RXH2 1/20 0.45
PKM P14618 1/20 0.45
UNG P13051 1/20 0.43
LCK P06239 1/20 0.41
SMN1; SMN2 Q16637 1/20 0.41
AR P10275 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31568503 1.00 MAOA (0.65) MAOAMAOBTSHRALDH1A1CYP2A6
SCHEMBL1662921 0.87 TSHR (0.58) MAOAMAOBTSHRALDH1A1CYP2A6
SCHEMBL6521194 0.86 MAOB (0.66) MAOAMAOBTSHRALDH1A1CYP2A6
SCHEMBL14328706 0.86 MAOA (0.58) MAOAMAOBTSHRALDH1A1CYP2A6
SCHEMBL12951679 0.84 RAB9A (0.69) MAOAMAOBALDH1A1CYP2A6RAB9A
SCHEMBL7672328 0.84 MAOA (0.53) MAOAMAOBALDH1A1RAB9ANPC1
SCHEMBL18002746 0.83 MAOA (0.60) MAOAMAOBALDH1A1RAB9ANPC1
SCHEMBL22436349 0.83 MAOA (0.50) MAOAMAOBALDH1A1RAB9ANPC1
SCHEMBL30688439 0.83 MAOA (0.50) MAOAMAOBALDH1A1RAB9ANPC1
SCHEMBL18003425 0.82 MAOB (0.47) MAOAMAOBRAB9ANPC1TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260108482-A1 MODULATORS OF MAS-RELATED G-PROTEIN RECEPTOR X4 AND RELATED PRODUCTS AND METHODS ESCIENT PHARMACEUTICALS INC (US) 2026-04-23 US disclosed
US-20240300907-A1 MODULATORS OF MAS-RELATED G-PROTEIN RECEPTOR X4 AND RELATED PRODUCTS AND METHODS INCYTE CORPORATION 2024-09-12 US disclosed
US-11840521-B2 Modulators of Mas-related G-protein receptor X4 and related products and methods ESCIENT PHARMACEUTICALS, INC. (US) 2023-12-12 US disclosed
US-20230159474-A1 MODULATORS OF MAS-RELATED G-PROTEIN RECEPTOR X4 AND RELATED PRODUCTS AND METHODS INCYTE CORPORATION 2023-05-25 US disclosed
US-11643399-B2 Modulators of mas-related G-protein receptor X4 and related products and methods ESCIENT PHARMACEUTICALS, INC. (US) 2023-05-09 US disclosed
US-20230053860-A1 MODULATORS OF MAS-RELATED G-PROTEIN RECEPTOR X4 AND RELATED PRODUCTS AND METHODS INCYTE CORPORATION 2023-02-23 US disclosed
EP-3946304-A1 MODULATORS OF MAS-RELATED G-PROTEIN RECEPTOR X4 AND RELATED PRODUCTS AND METHODS ESCIENT PHARMACEUTICALS, INC. (US) 2022-02-09 EP disclosed
US-20210032213-A1 MODULATORS OF MAS-RELATED G-PROTEIN RECEPTOR X4 AND RELATED PRODUCTS AND METHODS INCYTE CORPORATION 2021-02-04 US disclosed
WO-2020198537-A1 MODULATORS OF MAS-RELATED G-PROTEIN RECEPTOR X4 AND RELATED PRODUCTS AND METHODS ESCIENT PHARMACEUTICALS, INC. (US) 2020-10-01 WO disclosed
US-10565015-B2 Spiroketal-based C2-symmetric scaffold for asymmetric catalysis THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) 2020-02-18 US disclosed
US-20190084995-A1 Spiroketal-Based C2-Symmetric Scaffold For Asymmetric Catalysis THE REGENTS OF THE UNIVERSITY OF MICHIGAN 2019-03-21 US disclosed
EP-3077385-B1 HETEROARYL DERIVATIVES FOR THE TREATMENT OF RESPIRATORY DISEASES CHIESI FARM SPA (IT) 2017-10-04 EP disclosed
US-8680150-B2 Small molecule hematopoietic growth factor mimetic compounds that activate hematopoietic growth factor receptors LIGAND PHARMACEUTICALS, INC. (US) 2014-03-25 US disclosed
US-20110003851-A1 SMALL MOLECULE HEMATOPOIETIC GROWTH FACTOR MIMETIC COMPOUNDS THAT ACTIVATE HEMATOPOIETIC GROWTH FACTOR RECEPTORS LIGAND PHARMACEUTICALS, INC. (US) 2011-01-06 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11840521-B2 Modulators of Mas-related G-protein receptor X4 and related products and methods MRGPRX4, MRGPRX1, MRGPRX2 MAOA 2661/4885MAOB 2818/4885TSHR 98/4885
US-10565015-B2 Spiroketal-based C2-symmetric scaffold for asymmetric catalysis PKD2, OPA1, PKD1 MAOA 1144/4885MAOB 969/4885TSHR 2398/4885
US-11643399-B2 Modulators of mas-related G-protein receptor X4 and related products and methods MRGPRX4, MRGPRX1, MRGPRX2 MAOA 2661/4885MAOB 2818/4885TSHR 98/4885
US-20210032213-A1 MODULATORS OF MAS-RELATED G-PROTEIN RECEPTOR X4 AND RELATED PRODUCTS AND METHODS MRGPRX4, MRGPRX1, MRGPRX2 MAOA 2667/4885MAOB 2840/4885TSHR 99/4885
US-20260108482-A1 MODULATORS OF MAS-RELATED G-PROTEIN RECEPTOR X4 AND RELATED PRODUCTS AND METHODS MRGPRX4, MRGPRX1, MRGPRX2 MAOA 3145/4885MAOB 3154/4885TSHR 34/4885
US-20190084995-A1 Spiroketal-Based C2-Symmetric Scaffold For Asymmetric Catalysis PKD2, OPA1, PKD1 MAOA 1144/4885MAOB 969/4885TSHR 2398/4885
US-20110003851-A1 SMALL MOLECULE HEMATOPOIETIC GROWTH FACTOR MIMETIC COMPOUNDS THAT ACTIVATE HEMATOPOIETIC GROWTH FACTOR RECEPTORS MPL, CSF3R, CSF1R MAOA 4658/4885MAOB 4672/4885TSHR 870/4885
US-20230159474-A1 MODULATORS OF MAS-RELATED G-PROTEIN RECEPTOR X4 AND RELATED PRODUCTS AND METHODS MRGPRX4, MRGPRX1, MRGPRX2 MAOA 2661/4885MAOB 2818/4885TSHR 98/4885
US-20240300907-A1 MODULATORS OF MAS-RELATED G-PROTEIN RECEPTOR X4 AND RELATED PRODUCTS AND METHODS MRGPRX4, MRGPRX1, MRGPRX2 MAOA 2661/4885MAOB 2818/4885TSHR 98/4885
US-20230053860-A1 MODULATORS OF MAS-RELATED G-PROTEIN RECEPTOR X4 AND RELATED PRODUCTS AND METHODS MRGPRX4, MRGPRX1, MRGPRX2 MAOA 2661/4885MAOB 2818/4885TSHR 98/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.