SCHEMBL6522908

SCHEMBL6522908

CCO[SiH2]C(C)(C)CCNC(=O)CBr

nearest known ligand 0.33

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 1/20 0.33
KMT2A Q03164 1/20 0.33
FAAH O00519 1/20 0.33
HDAC3 O15379 2/20 0.31
HDAC4 P56524 2/20 0.31
HDAC1 Q13547 2/20 0.31
HDAC7 Q8WUI4 2/20 0.31
HDAC2 Q92769 2/20 0.31
HDAC10 Q969S8 2/20 0.31
HDAC11 Q96DB2 2/20 0.31
HDAC8 Q9BY41 2/20 0.31
HDAC6 Q9UBN7 2/20 0.31
HDAC9 Q9UKV0 2/20 0.31
HDAC5 Q9UQL6 2/20 0.31
GAA P10253 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL978494 0.73
SCHEMBL3310816 0.67
SCHEMBL459746 0.66 EPHX2 (0.42) MEN1KMT2A
SCHEMBL4997115 0.66
SCHEMBL4885718 0.66 MEN1 (0.34) MEN1KMT2AFAAHHDAC3HDAC4
SCHEMBL16853223 0.65 ALDH1A1 (0.48) MEN1KMT2AFAAHHDAC3HDAC4
SCHEMBL16853220 0.65 ALDH1A1 (0.55) MEN1KMT2AFAAHHDAC3HDAC4
SCHEMBL462832 0.65 CASP2 (0.63) MEN1KMT2AFAAH
SCHEMBL10866810 0.65 HDAC3 (0.41) MEN1KMT2AFAAHHDAC3HDAC4
SCHEMBL6522913 0.65 ALDH1A1 (0.39)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20050032084-A1 Method of attaching a biopolymer to a solid support DUKE UNIVERSITY (US) 2005-02-10 US disclosed
US-20020076832-A1 Method of attaching a biopolymer to a solid support DUKE UNIVERSITY 2002-06-20 US disclosed