Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 10/20 | 0.50 |
| ▸ | ALOX5 | P09917 | 10/20 | 0.49 |
| ▸ | CSNK1D | P48730 | 3/20 | 0.47 |
| ▸ | JAK3 | P52333 | 1/20 | 0.47 |
| ▸ | MAPK11 | Q15759 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.45 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | CSNK1A1L | Q8N752 | 1/20 | 0.45 |
| ▸ | MAPK13 | O15264 | 3/20 | 0.44 |
| ▸ | MAPK12 | P53778 | 3/20 | 0.44 |
| ▸ | GCGR | P47871 | 2/20 | 0.44 |
| ▸ | RAF1 | P04049 | 1/20 | 0.44 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.44 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4585785 | 0.88 | ALOX5 (0.64) | MAPK14ALOX5CSNK1DJAK3MAPK11 | |
| SCHEMBL6471800 | 0.81 | MAPK14 (0.49) | MAPK14ALOX5CSNK1DJAK3MAPK11 | |
| SCHEMBL4586510 | 0.79 | MAPK14 (0.61) | MAPK14ALOX5CSNK1DJAK3MAPK11 | |
| SCHEMBL4586451 | 0.77 | MAPK14 (0.51) | MAPK14ALOX5CSNK1DJAK3MAPK11 | |
| SCHEMBL4584148 | 0.77 | ALOX5 (0.58) | MAPK14ALOX5CSNK1DJAK3MAPK11 | |
| SCHEMBL5078081 | 0.72 | ALOX5 (0.76) | MAPK14ALOX5CSNK1DMAPK11ALDH1A1 | |
| SCHEMBL4586521 | 0.72 | MAPK14 (0.51) | MAPK14ALOX5CSNK1DJAK3MAPK11 | |
| SCHEMBL4977359 | 0.72 | MAPK14 (0.56) | MAPK14ALOX5CSNK1DJAK3MAPK11 | |
| SCHEMBL8113515 | 0.70 | CSNK1D (0.56) | MAPK14CSNK1DJAK3MAPK11CSNK1A1 | |
| SCHEMBL7665444 | 0.69 | MAPK14 (0.52) | MAPK14CSNK1DJAK3MAPK11CSNK1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005030091-A2 | STENTS AND INTRA-LUMINAL PROSTHESES CONTAINING MAP KINASE INHIBITORS | SCIOS INC. (US) | 2005-04-07 | — | — | WO | disclosed |