Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 12/20 | 0.56 |
| ▸ | MAPK11 | Q15759 | 6/20 | 0.55 |
| ▸ | MAPK13 | O15264 | 5/20 | 0.55 |
| ▸ | MAPK12 | P53778 | 5/20 | 0.55 |
| ▸ | ALOX5 | P09917 | 4/20 | 0.55 |
| ▸ | RAF1 | P04049 | 3/20 | 0.55 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.55 |
| ▸ | GCGR | P47871 | 2/20 | 0.55 |
| ▸ | CSNK1D | P48730 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.55 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | CSNK1A1L | Q8N752 | 1/20 | 0.55 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.54 |
| ▸ | EGFR | P00533 | 2/20 | 0.53 |
| ▸ | JAK3 | P52333 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4974887 | 0.80 | MAPK14 (0.81) | MAPK14MAPK11MAPK13MAPK12ALOX5 | |
| SCHEMBL4975933 | 0.76 | MAPK14 (0.85) | MAPK14MAPK11MAPK13MAPK12ALOX5 | |
| SCHEMBL2410945 | 0.76 | RAB9A (0.56) | ALDH1A1SMN1; SMN2TGFBR1 | |
| SCHEMBL4552049 | 0.76 | ALOX5 (0.73) | MAPK14MAPK11MAPK13MAPK12ALOX5 | |
| SCHEMBL5771534 | 0.75 | MAPK13 (0.46) | MAPK14MAPK11MAPK13MAPK12 | |
| SCHEMBL7485716 | 0.75 | MAPK14 (0.63) | MAPK14MAPK11MAPK13MAPK12ALOX5 | |
| SCHEMBL1629037 | 0.75 | MAPK13 (0.85) | MAPK14MAPK11MAPK13MAPK12ALOX5 | |
| SCHEMBL16292225 | 0.75 | MAPK13 (0.85) | MAPK14MAPK11MAPK13MAPK12ALOX5 | |
| SCHEMBL5770353 | 0.74 | MAPK13 (0.45) | MAPK14MAPK11MAPK13MAPK12 | |
| SCHEMBL5770929 | 0.74 | MAPK13 (0.53) | MAPK14MAPK11MAPK13MAPK12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101426503-A | Compositions and methods of treatment for inhibiting kinase and/or HMG-COA reductase | PHARMIX CORP (US) | 2009-05-06 | — | — | CN | disclosed |
| US-20080021054-A1 | COMPOSITIONS AND TREATMENTS FOR INHIBITING KINASE AND/OR HMG-COA REDUCTASE | NUMERATE, INC. | 2008-01-24 | — | — | US | disclosed |
| US-20080021054-A1 | COMPOSITIONS AND TREATMENTS FOR INHIBITING KINASE AND/OR HMG-COA REDUCTASE | NUMERATE, INC. | 2008-01-24 | — | — | US | disclosed |
| US-20080021054-A1 | COMPOSITIONS AND TREATMENTS FOR INHIBITING KINASE AND/OR HMG-COA REDUCTASE | NUMERATE, INC. | 2008-01-24 | — | — | US | disclosed |
| US-7199126-B2 | Compositions and treatments for inhibiting kinase and/or HMG-CoA reductase | PHARMIX CORPORATION (US) | 2007-04-03 | — | — | US | disclosed |
| US-7199126-B2 | Compositions and treatments for inhibiting kinase and/or HMG-CoA reductase | PHARMIX CORPORATION (US) | 2007-04-03 | — | — | US | disclosed |
| US-7199126-B2 | Compositions and treatments for inhibiting kinase and/or HMG-CoA reductase | PHARMIX CORPORATION (US) | 2007-04-03 | — | — | US | disclosed |
| EP-1755607-A2 | COMPOSITIONS AND TREATMENTS FOR INHIBITING KINASE AND/OR HMG-COA REDUCTASE | Pharmix Corporation (US) | 2007-02-28 | — | — | EP | disclosed |
| US-7183285-B2 | Compositions and treatments for inhibiting kinase and/or HMG-CoA reductase | PHARMIX CORP. (US) | 2007-02-27 | — | — | US | disclosed |
| US-7183285-B2 | Compositions and treatments for inhibiting kinase and/or HMG-CoA reductase | PHARMIX CORP. (US) | 2007-02-27 | — | — | US | disclosed |
| US-20070004758-A1 | COMPOSITIONS AND TREATMENTS FOR INHIBITING KINASE AND/OR HMG-COA REDUCTASE | NUMERATE, INC. | 2007-01-04 | — | — | US | disclosed |
| US-20070004758-A1 | COMPOSITIONS AND TREATMENTS FOR INHIBITING KINASE AND/OR HMG-COA REDUCTASE | NUMERATE, INC. | 2007-01-04 | — | — | US | disclosed |
| US-20070004758-A1 | COMPOSITIONS AND TREATMENTS FOR INHIBITING KINASE AND/OR HMG-COA REDUCTASE | NUMERATE, INC. | 2007-01-04 | — | — | US | disclosed |
| US-20060084695-A1 | Compositions and treatments for inhibiting kinase and/or HMG-CoA reductase | NUMERATE, INC. | 2006-04-20 | — | — | US | disclosed |
| WO-2006028524-A2 | COMPOSITIONS AND TREATMENTS FOR INHIBITING KINASE AND/OR HMG-COA REDUCTASE | PHARMIX CORPORATION (US) | 2006-03-16 | — | — | WO | disclosed |
| US-20050288306-A1 | Compositions and treatments for inhibiting kinase and/or HMG-CoA reductase | NUMERATE, INC. | 2005-12-29 | — | — | US | disclosed |
| US-20050282883-A1 | Compositions and treatments for inhibiting kinase and/or HMG-CoA reductase | NUMERATE, INC. | 2005-12-22 | — | — | US | disclosed |
| US-20050277653-A1 | Compositions and treatments for inhibiting kinase and/or HMG-CoA reductase | NUMERATE, INC. | 2005-12-15 | — | — | US | disclosed |
| US-20050272770-A1 | Compositions and treatments for inhibiting kinase and/or HMG-CoA reductase | NUMERATE, INC. | 2005-12-08 | — | — | US | disclosed |
| US-20050261354-A1 | Compositions and treatments for inhibiting kinase and/or HMG-CoA reductase | NUMERATE, INC. | 2005-11-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050288306-A1 | Compositions and treatments for inhibiting kinase and/or HMG-CoA reductase | HMGCR, HMGB3, HMGB2 | MAPK14 198/4885MAPK11 213/4885MAPK13 189/4885 |
| US-20050282883-A1 | Compositions and treatments for inhibiting kinase and/or HMG-CoA reductase | HMGCR, HMGB3, HMGB2 | MAPK14 224/4885MAPK11 235/4885MAPK13 201/4885 |
| US-20060084695-A1 | Compositions and treatments for inhibiting kinase and/or HMG-CoA reductase | HMGCR, HMGB3, HMGB2 | MAPK14 198/4885MAPK11 213/4885MAPK13 189/4885 |
| US-20050277653-A1 | Compositions and treatments for inhibiting kinase and/or HMG-CoA reductase | HMGCR, HMGB3, HMGB2 | MAPK14 198/4885MAPK11 213/4885MAPK13 189/4885 |
| US-20070004758-A1 | COMPOSITIONS AND TREATMENTS FOR INHIBITING KINASE AND/OR HMG-COA REDUCTASE | HMGCR, HMGB3, HMGB2 | MAPK14 198/4885MAPK11 213/4885MAPK13 189/4885 |
| US-20050261354-A1 | Compositions and treatments for inhibiting kinase and/or HMG-CoA reductase | HMGCR, HMGB3, HMGB2 | MAPK14 198/4885MAPK11 213/4885MAPK13 189/4885 |
| US-20080021054-A1 | COMPOSITIONS AND TREATMENTS FOR INHIBITING KINASE AND/OR HMG-COA REDUCTASE | HMGCR, HMGB3, HMGB2 | MAPK14 198/4885MAPK11 213/4885MAPK13 189/4885 |
| US-20050272770-A1 | Compositions and treatments for inhibiting kinase and/or HMG-CoA reductase | HMGCR, HMGB3, HMGB2 | MAPK14 198/4885MAPK11 213/4885MAPK13 189/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.