SCHEMBL6526591

SCHEMBL6526591

COc1c(C)ccc2c3cc(Cl)ccc3n(Cc3ccc(F)cc3)c12

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RXFP1 Q9HBX9 1/20 0.47
KDM4E B2RXH2 3/20 0.42
CYP1A2 P05177 3/20 0.42
CYP3A4 P08684 3/20 0.42
CYP2C9 P11712 3/20 0.42
TSHR P16473 3/20 0.42
CYP2C19 P33261 3/20 0.42
LMNA P02545 2/20 0.42
PMP22 Q01453 2/20 0.42
BLM P54132 1/20 0.42
NPSR1 Q6W5P4 1/20 0.42
PIK3R1 P27986 1/20 0.41
PIK3CA P42336 1/20 0.41
MAPT P10636 5/20 0.40
HIF1A Q16665 2/20 0.40
HPGD P15428 1/20 0.40
HSD17B10 Q99714 1/20 0.40
PTGES2 Q9H7Z7 1/20 0.40
TDP1 Q9NUW8 1/20 0.40
PTGS2 P35354 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5025162 0.84 CYP3A4 (0.45) KDM4ECYP1A2CYP3A4CYP2C9TSHR
SCHEMBL5546412 0.79 CYP1A2 (0.46) RXFP1KDM4ECYP1A2CYP3A4CYP2C9
SCHEMBL21465503 0.74 ABCB11 (0.51) KDM4ECYP1A2CYP3A4CYP2C9TSHR
SCHEMBL31019833 0.71 CCR2 (0.58) KDM4ECYP1A2CYP3A4CYP2C9TSHR
SCHEMBL5541552 0.70 CYP1A2 (0.45) KDM4ECYP1A2CYP3A4CYP2C9TSHR
SCHEMBL5546407 0.70 LMNA (0.45) KDM4ECYP1A2CYP3A4CYP2C9TSHR
SCHEMBL21465614 0.67 MAPT (0.47) KDM4ECYP1A2CYP3A4CYP2C9TSHR
SCHEMBL21465632 0.67 PTGDR2 (0.51) KDM4ECYP1A2CYP3A4CYP2C9TSHR
SCHEMBL21465513 0.66 PTGDR2 (0.55) KDM4ECYP1A2CYP3A4CYP2C9TSHR
SCHEMBL21465476 0.66 ABCB11 (0.68) KDM4ECYP1A2CYP3A4CYP2C9TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1554262-A1 NOVEL TRICYCLIC COMPOUNDS USEFUL FOR THE TREATMENT OF INFLAMMATORY AND ALLERGIC DISORDERS: PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM Glenmark Pharmaceuticals Limited (IN) 2005-07-20 EP disclosed
WO-2004037805-A1 NOVEL TRICYCLIC COMPOUNDS USEFUL FOR THE TREATMENT OF INFLAMMATORY AND ALLERGIC DISORDERS: PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM GLENMARK PHARMACEUTICALS LTD. (US) 2004-05-06 WO disclosed