Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.39 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL653285 | 0.85 | DYRK1A (0.41) | SMN1; SMN2NPC1GAARAB9ADYRK1A | |
| SCHEMBL651209 | 0.85 | CYP1A2 (0.46) | MEN1KMT2AABCG2SMN1; SMN2NPC1 | |
| SCHEMBL4086452 | 0.81 | MAPK1 (0.46) | MEN1KMT2ASMN1; SMN2NPC1GAA | |
| SCHEMBL653933 | 0.80 | MEN1 (0.43) | MEN1KMT2AABCG2SMN1; SMN2NPC1 | |
| SCHEMBL4088328 | 0.80 | MAPK1 (0.41) | MEN1KMT2ASMN1; SMN2NPC1HTT | |
| SCHEMBL4088806 | 0.80 | HSD17B13 (0.42) | SMN1; SMN2NPC1CYP3A4RAB9AKDM4E | |
| SCHEMBL652872 | 0.80 | BDKRB1 (0.45) | MEN1KMT2ACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL653508 | 0.80 | BDKRB1 (0.45) | MEN1KMT2ACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL4083945 | 0.78 | MAPK1 (0.45) | MEN1KMT2ASMN1; SMN2NPC1GAA | |
| SCHEMBL4088568 | 0.77 | CDK2 (0.40) | SMN1; SMN2NPC1CYP3A4RAB9AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8119641-B2 | 1H-furo[3,2-C]pyrazole compounds useful as kinase inhibitors | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2012-02-21 | — | — | US | disclosed |