Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.66 |
| ▸ | MAPT | P10636 | 4/20 | 0.60 |
| ▸ | APP | P05067 | 1/20 | 0.60 |
| ▸ | GSK3B | P49841 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.55 |
| ▸ | BACE1 | P56817 | 2/20 | 0.54 |
| ▸ | GLA | P06280 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.52 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.52 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.52 |
| ▸ | TNKS | O95271 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10348533 | 1.00 | HAO1 (0.66) | HAO1MAPTAPPGSK3BALDH1A1 | |
| SCHEMBL27435225 | 0.92 | HAO1 (0.60) | HAO1MAPTAPPGSK3BALDH1A1 | |
| SCHEMBL316674 | 0.87 | HAO1 (0.84) | HAO1MAPTAPPGSK3BALDH1A1 | |
| SCHEMBL3439644 | 0.87 | HAO1 (0.84) | HAO1MAPTAPPGSK3BALDH1A1 | |
| SCHEMBL3105207 | 0.86 | HAO1 (0.62) | HAO1MAPTAPPGSK3BALDH1A1 | |
| SCHEMBL3105202 | 0.86 | HAO1 (0.62) | HAO1MAPTAPPGSK3BALDH1A1 | |
| Dimethylamine SCHEMBL14875132 | 0.85 | HAO1 (0.75) | HAO1MAPTAPPGSK3BALDH1A1 | |
| SCHEMBL8467852 | 0.84 | AKR1B1 (0.76) | GSK3BBACE1MAOBAKR1B10AKR1B1 | |
| SCHEMBL6954034 | 0.83 | BACE1 (0.55) | MAPTAPPGSK3BALDH1A1MEN1 | |
| SCHEMBL10759485 | 0.83 | GSK3B (0.60) | MAPTGSK3BALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 51 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0239105-B1 | PHARMACEUTICAL COMPOSITIONS CONTAINING 5-PHENYL-1,3-DIOXOALKENYL COMPOUNDS | G.D. Searle & Co. (US) | 1990-05-23 | — | — | EP | claimed |
| EP-0239105-A2 | Pharmaceutical compositions containing 5-phenyl-1,3-dioxoalkenyl compounds | G.D. Searle & Co. (US) | 1987-09-30 | — | — | EP | claimed |
| US-20050209117-A1 | Complexing agent for treating metallic and plastic surfaces | BASF AKTIENGESELLSCHAFT (DE) | 2005-09-22 | — | — | US | disclosed |
| EP-1023267-B1 | PYRIDYL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | CERMOL SA (CH) | 2003-09-17 | — | — | EP | disclosed |
| US-6482841-B1 | Pyridyl compounds and pharmaceutical compositions containing them | CERMOL S.A. (CH) | 2002-11-19 | — | — | US | disclosed |
| EP-1023267-A1 | PYRIDYL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | CERMOL S.A. (CH) | 2000-08-02 | — | — | EP | disclosed |
| US-5951841-A | ACIDIC ELECTROPLATING BATHS COMPRISING BRIGHTENERS FOR THE ELECTROLYTIC DEPOSITION OF METALLIC INORGANIC LAYERS ONTO SHAPED ARTICLES | BASF AKTIENGESELLSCHAFT (DE) | 1999-09-14 | — | — | US | disclosed |
| WO-1999019302-A1 | PYRIDYL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | CERMOL S.A. (CH) | 1999-04-22 | — | — | WO | disclosed |
| US-5421990-A | An acidic aqueous electrodeposition bath having a nontoxic, nonirritating brightener comprising a benzylidine malonic ester or acetylacetonate | BASF AKTIENGESELLSCHAFT (DE) | 1995-06-06 | — | — | US | disclosed |
| EP-0239105-B1 | PHARMACEUTICAL COMPOSITIONS CONTAINING 5-PHENYL-1,3-DIOXOALKENYL COMPOUNDS | G.D. Searle & Co. (US) | 1990-05-23 | — | — | EP | disclosed |
| US-4898877-A | ANTIARRHYTHMIA AGENTS | BAYER AKTIENGESELLSCHAFT (DE) | 1990-02-06 | — | — | US | disclosed |
| US-3951994-A | HYPOTENSIVE, CORONARY VESSEL DILATORS | BAYER AKTIENGESELLSCHAFT (DT) | 1976-04-20 | — | — | US | disclosed |
| US-3948923-A | HYPOTENSIVE, VASODILATION | BAYER AKTIENGESELLSCHAFT (DT) | 1976-04-06 | — | — | US | disclosed |
| US-3946026-A | HYPOTENSIVE AGENTS, CORONARY VESSEL DILATORS | BAYER AKTIENGESELLSCHAFT (DT) | 1976-03-23 | — | — | US | disclosed |
| US-3946028-A | HYPOTENSIVE AGENTS, CORONARY VESSEL DILATORS | BAYER AKTIENGESELLSCHAFT (DT) | 1976-03-23 | — | — | US | disclosed |
| US-3946027-A | HYPOTENSIVE AGENTS, CORONARY VESSEL DILATORS | BAYER AKTIENGESELLSCHAFT (DT) | 1976-03-23 | — | — | US | disclosed |
| US-3943140-A | HYPOTENSIVE, VASODILATION | BAYER AKTIENGESELLSCHAFT (DT) | 1976-03-09 | — | — | US | disclosed |
| US-3939171-A | HYPOTENSIVE, VASODILATION | BAYER AKTIENGESELLSCHAFT (DT) | 1976-02-17 | — | — | US | disclosed |
| US-3935220-A | VASODILATION, HYPOTENSIVE | BAYER AKTIENGESELLSCHAFT (DT) | 1976-01-27 | — | — | US | disclosed |
| US-3935223-A | 2-Amino-1,4-dihydropyridine derivatives | BAYER AKTIENGESELLSCHAFT (DT) | 1976-01-27 | — | — | US | disclosed |