Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.62 |
| ▸ | RAB9A | P51151 | 5/20 | 0.57 |
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | APP | P05067 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.53 |
| ▸ | GSK3B | P49841 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 3/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | BACE1 | P56817 | 1/20 | 0.51 |
| ▸ | EGFR | P00533 | 2/20 | 0.50 |
| ▸ | MAOA | P21397 | 1/20 | 0.50 |
| ▸ | MAOB | P27338 | 1/20 | 0.50 |
| ▸ | GLA | P06280 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3105207 | 1.00 | HAO1 (0.62) | HAO1RAB9AMAPTNPSR1APP | |
| SCHEMBL11741671 | 0.91 | HDAC2 (0.54) | HAO1RAB9AMAPTNPSR1APP | |
| SCHEMBL7423204 | 0.87 | HAO1 (0.63) | HAO1RAB9AMAPTNPSR1APP | |
| SCHEMBL7423208 | 0.87 | HAO1 (0.63) | HAO1RAB9AMAPTNPSR1APP | |
| SCHEMBL11547026 | 0.87 | RAB9A (0.57) | RAB9AMAPTALDH1A1KMT2AKDM4E | |
| SCHEMBL6526696 | 0.86 | HAO1 (0.66) | HAO1RAB9AMAPTAPPALDH1A1 | |
| SCHEMBL10348533 | 0.86 | HAO1 (0.66) | HAO1RAB9AMAPTAPPALDH1A1 | |
| SCHEMBL12165488 | 0.86 | HAO1 (0.57) | HAO1RAB9AMAPTNPSR1APP | |
| SCHEMBL7660175 | 0.86 | ALDH1A1 (0.54) | RAB9AMAPTNPSR1ALDH1A1MEN1 | |
| SCHEMBL5369201 | 0.85 | ALDH1A1 (0.65) | HAO1RAB9AMAPTNPSR1APP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0239105-B1 | PHARMACEUTICAL COMPOSITIONS CONTAINING 5-PHENYL-1,3-DIOXOALKENYL COMPOUNDS | G.D. Searle & Co. (US) | 1990-05-23 | — | — | EP | claimed |
| EP-0239105-A2 | Pharmaceutical compositions containing 5-phenyl-1,3-dioxoalkenyl compounds | G.D. Searle & Co. (US) | 1987-09-30 | — | — | EP | claimed |
| US-9133488-B2 | Synthetic methods and compounds related thereto | UNIVERSITY OF ALASKA FAIRBANKS (US) | 2015-09-15 | — | — | US | disclosed |
| US-8637674-B2 | Pyrazole derivatives, preparation method thereof, and composition for prevention and treatment of osteoporosis containing same | EWHA UNIVERSITY-INDUSTRY COLLABORATION FOUNDATION (KR) | 2014-01-28 | — | — | US | disclosed |
| US-20120232117-A1 | PYRAZOLE DERIVATIVES, PREPARATION METHOD THEREOF, AND COMPOSITION FOR PREVENTION AND TREATMENT OF OSTEOPOROSIS CONTAINING SAME | EWHA UNIVERSITY-INDUSTRY COLLABORATION FOUNDATION (KR) | 2012-09-13 | — | — | US | disclosed |
| US-7803822-B2 | Triazole derivative and use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-09-28 | — | — | US | disclosed |
| EP-1481961-B1 | PROCESS FOR PRODUCING (R)-3-HYDROXY-3-(2-PHENYLETHYL)HEXANOIC ACID AND ITS INTERMEDIATE | SUMITOMO CHEMICAL CO (JP) | 2009-11-25 | — | — | EP | disclosed |
| CN-100528828-C | Production method of racemiation3-hydroxy-3- (2-phenylethyl) hexanoic acid C1-6 alkyl ester | SUMIKA FINE CHEMICALS CO LTD (JP) | 2009-08-19 | — | — | CN | disclosed |
| EP-1894912-B1 | Process for producing racemic 3-hydroxy-3-(2-phenylethyl) hexanoic acid ester | SUMITOMO CHEMICAL CO (JP) | 2009-08-05 | — | — | EP | disclosed |
| US-20090105253-A1 | Triazole Derivative and Use Thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-04-23 | — | — | US | disclosed |
| EP-1894912-A1 | Process for producing racemic 3-hydroxy-3-(2-phenylethyl) hexanoic acid ester | Sumitomo Chemical Company, Limited (JP) | 2008-03-05 | — | — | EP | disclosed |
| US-20040138496-A1 | Production method of (R)-3- hydroxy-3-(2-phenylethyl)hexanoic acid and intermediate thereof | SUMIKA FINE CHEMICALS CO., LTD. (JP) | 2004-07-15 | — | — | US | disclosed |
| US-6683207-B2 | RESOLUTION USING 1-AMINO-1-PHENYLETHANE DERIVATIVE | SUMIKA FINE CHEMICALS CO., LTD. (JP) | 2004-01-27 | — | — | US | disclosed |
| US-20030176507-A1 | Production method of (R) -3 hydroxy-3- (2-phenylethyl) hexanoic acid and intermediate thereof | SUMIKA FINE CHEMICALS CO., LTD. (JP) | 2003-09-18 | — | — | US | disclosed |
| US-5144057-A | Process for the production of 3-oxocarboxylic acid esters | LONZA LTD. (CH) | 1992-09-01 | — | — | US | disclosed |
| EP-0239105-B1 | PHARMACEUTICAL COMPOSITIONS CONTAINING 5-PHENYL-1,3-DIOXOALKENYL COMPOUNDS | G.D. Searle & Co. (US) | 1990-05-23 | — | — | EP | disclosed |
| US-4898877-A | ANTIARRHYTHMIA AGENTS | BAYER AKTIENGESELLSCHAFT (DE) | 1990-02-06 | — | — | US | disclosed |
| US-4761503-A | LEUKOTRIENE BIOSYNTHESIS INHIBITORS CONDENSATION OF BENZALDEHYDE WITH ACETOACETATE COMPOUND | G. D. SEARLE & CO. (US) | 1988-08-02 | — | — | US | disclosed |
| EP-0239105-A2 | Pharmaceutical compositions containing 5-phenyl-1,3-dioxoalkenyl compounds | G.D. Searle & Co. (US) | 1987-09-30 | — | — | EP | disclosed |
| US-4649157-A | ANTIALLERGENS, ANTIINFLAMMATORY | G. D. SEARLE & CO. (US) | 1987-03-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040138496-A1 | Production method of (R)-3- hydroxy-3-(2-phenylethyl)hexanoic acid and intermediate thereof | HAAO, HPD, HAO2 | HAO1 5/4885RAB9A 977/4885MAPT 2710/4885 |
| US-20090105253-A1 | Triazole Derivative and Use Thereof | F2R, HRH4, F2RL3 | HAO1 406/4885RAB9A 2959/4885MAPT 4724/4885 |
| US-20120232117-A1 | PYRAZOLE DERIVATIVES, PREPARATION METHOD THEREOF, AND COMPOSITION FOR PREVENTION AND TREATMENT OF OSTEOPOROSIS CONTAINING SAME | PTH1R, VDR, SOST | HAO1 3880/4885RAB9A 1632/4885MAPT 3099/4885 |
| US-20030176507-A1 | Production method of (R) -3 hydroxy-3- (2-phenylethyl) hexanoic acid and intermediate thereof | HAAO, HPD, HAO2 | HAO1 5/4885RAB9A 1203/4885MAPT 3351/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.