Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 3/20 | 0.55 |
| ▸ | APP | P05067 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | P4HB | P07237 | 1/20 | 0.55 |
| ▸ | MMP9 | P14780 | 10/20 | 0.54 |
| ▸ | MMP1 | P03956 | 9/20 | 0.54 |
| ▸ | MMP2 | P08253 | 9/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.54 |
| ▸ | TSHR | P16473 | 2/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.54 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.54 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.54 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.54 |
| ▸ | MAOA | P21397 | 2/20 | 0.54 |
| ▸ | MAOB | P27338 | 2/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | PTGES | O14684 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16589019 | 0.90 | BACE1 (0.64) | BACE1MMP9MMP1MMP2AKR1B1 | |
| SCHEMBL6955898 | 0.85 | NFE2L2 (0.50) | BACE1APPMAPTMMP9MMP1 | |
| SCHEMBL6954978 | 0.85 | BACE1 (0.68) | BACE1APPMAPTMMP9CYP2D6 | |
| SCHEMBL10666536 | 0.85 | MAOB (0.59) | BACE1MAPTCYP2D6NFE2L2MAOA | |
| SCHEMBL6960590 | 0.85 | CYP1A2 (0.59) | APPMAPTMMP9MMP1MMP2 | |
| SCHEMBL10666534 | 0.85 | MAOB (0.59) | BACE1MAPTCYP2D6NFE2L2MAOA | |
| SCHEMBL16588975 | 0.84 | MMP1 (0.66) | BACE1APPMAPTP4HBMMP9 | |
| SCHEMBL3211603 | 0.84 | BACE1 (0.75) | BACE1MMP9MMP1MMP2ABCB1 | |
| SCHEMBL3211591 | 0.84 | BACE1 (0.75) | BACE1MMP9MMP1MMP2ABCB1 | |
| SCHEMBL11549203 | 0.84 | P4HB (0.61) | BACE1APPMAPTP4HBMMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1023267-B1 | PYRIDYL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | CERMOL SA (CH) | 2003-09-17 | — | — | EP | disclosed |
| US-6482841-B1 | Pyridyl compounds and pharmaceutical compositions containing them | CERMOL S.A. (CH) | 2002-11-19 | — | — | US | disclosed |
| EP-1023267-A1 | PYRIDYL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | CERMOL S.A. (CH) | 2000-08-02 | — | — | EP | disclosed |
| US-5951841-A | ACIDIC ELECTROPLATING BATHS COMPRISING BRIGHTENERS FOR THE ELECTROLYTIC DEPOSITION OF METALLIC INORGANIC LAYERS ONTO SHAPED ARTICLES | BASF AKTIENGESELLSCHAFT (DE) | 1999-09-14 | — | — | US | disclosed |
| WO-1999019302-A1 | PYRIDYL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | CERMOL S.A. (CH) | 1999-04-22 | — | — | WO | disclosed |