Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 5/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | DPP8 | Q6V1X1 | 4/20 | 0.38 |
| ▸ | DPP7 | Q9UHL4 | 4/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | ADCY1 | Q08828 | 4/20 | 0.33 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | ADCY8 | P40145 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6528894 | 0.86 | DPP4 (0.52) | DPP4PKMDPP8DPP7LMNA | |
| SCHEMBL6527981 | 0.85 | DPP4 (0.57) | DPP4PKMDPP8DPP7LMNA | |
| SCHEMBL6529451 | 0.84 | DPP4 (0.40) | DPP4PKMDPP8DPP7SMN1; SMN2 | |
| SCHEMBL6527697 | 0.81 | DPP4 (0.41) | DPP4DPP8DPP7L3MBTL1ALDH1A1 | |
| SCHEMBL6529125 | 0.77 | DPP4 (0.61) | DPP4PKMDPP8DPP7LMNA | |
| SCHEMBL6532303 | 0.77 | DPP4 (0.76) | DPP4PKMDPP8DPP7 | |
| SCHEMBL6532892 | 0.76 | DPP4 (0.53) | DPP4DPP8DPP7L3MBTL1ALDH1A1 | |
| SCHEMBL6530976 | 0.71 | ACKR3 (0.39) | DPP4DPP8DPP7TSHRPOLB | |
| SCHEMBL6530305 | 0.71 | DPP4 (0.72) | DPP4PKMDPP8DPP7LMNA | |
| SCHEMBL6529519 | 0.71 | DPP4 (0.74) | DPP4PKMDPP8DPP7LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005037828-A1 | NOVEL INHIBITORS OF DPP-IV, METHODS OF PREPARING THE SAME, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AS AN ACTIVE AGENT | LG LIFE SCIENCES LTD. (KR) | 2005-04-28 | — | — | WO | disclosed |