Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.35 |
| ▸ | CFTR | P13569 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | RAD52 | P43351 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.34 |
| ▸ | BTK | Q06187 | 1/20 | 0.33 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.33 |
| ▸ | CDC7 | O00311 | 1/20 | 0.33 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.33 |
| ▸ | SYK | P43405 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6528749 | 0.90 | MEN1 (0.37) | CFTRTP53POLBMAPTMEN1 | |
| SCHEMBL6528784 | 0.87 | GALR2 (0.37) | CFTRPOLBSYKCYP1A2CYP2D6 | |
| SCHEMBL6531461 | 0.87 | EGFR (0.39) | CFTRTP53POLBMAPTMEN1 | |
| SCHEMBL6528279 | 0.87 | GALR2 (0.38) | SYKCYP1A2CYP2D6CYP2C19 | |
| SCHEMBL6530216 | 0.87 | NPC1 (0.38) | POLBMAPK1HPGDALDH1A1 | |
| SCHEMBL6533478 | 0.86 | ITK (0.36) | CFTRTP53POLBMAPTMEN1 | |
| SCHEMBL6529648 | 0.86 | PDPK1 (0.41) | POLBMEN1KMT2ABTKMAPK1 | |
| SCHEMBL6528183 | 0.86 | TBK1 (0.34) | TBK1CFTRTP53POLBMAPT | |
| SCHEMBL6529551 | 0.86 | CHRNA7 (0.35) | CFTRTP53POLBMAPTMEN1 | |
| SCHEMBL6530876 | 0.85 | MAPT (0.38) | POLBMAPTMEN1KMT2AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005003103-A2 | 2, 4, 6-TRI-SUBSTITUTED 6-MEMBERED HETEROCYCLES AND THEIR USE IN THE TREATMENT OF NEURODEGENERATIVE DISEASES | ASTRAZENECA AB (SE) | 2005-01-13 | — | — | WO | disclosed |