Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | CFTR | P13569 | 2/20 | 0.34 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | RAD52 | P43351 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | SYK | P43405 | 1/20 | 0.32 |
| ▸ | BTK | Q06187 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6530633 | 0.91 | CDC7 (0.35) | MAPTPOLBCFTRCHRNA7RXFP1 | |
| SCHEMBL6532660 | 0.87 | MAPT (0.36) | MAPTPOLBCFTRCHRNA7RXFP1 | |
| SCHEMBL6528181 | 0.86 | TBK1 (0.35) | TBK1MAPTPOLBCFTRCHRNA7 | |
| SCHEMBL6529056 | 0.86 | KMT2A (0.38) | MEN1KMT2AALDH1A1CYP1A2CYP2D6 | |
| SCHEMBL6533479 | 0.86 | ITK (0.35) | MAPTPOLBCFTRCHRNA7RXFP1 | |
| SCHEMBL6531968 | 0.85 | POLB (0.39) | MAPTPOLBMEN1KMT2ASYK | |
| SCHEMBL6528847 | 0.80 | SYK (0.43) | CHRNA7SCN9AMEN1KMT2AALDH1A1 | |
| SCHEMBL6528749 | 0.78 | MEN1 (0.37) | MAPTPOLBCFTRCHRNA7TP53 | |
| SCHEMBL6508192 | 0.76 | KCNH3 (0.41) | MAPTPOLBCHRNA7TP53MEN1 | |
| SCHEMBL6508189 | 0.76 | KCNH3 (0.41) | MAPTPOLBCHRNA7TP53MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005003103-A2 | 2, 4, 6-TRI-SUBSTITUTED 6-MEMBERED HETEROCYCLES AND THEIR USE IN THE TREATMENT OF NEURODEGENERATIVE DISEASES | ASTRAZENECA AB (SE) | 2005-01-13 | — | — | WO | disclosed |