Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.60 |
| ▸ | HPGD | P15428 | 3/20 | 0.60 |
| ▸ | MAPT | P10636 | 2/20 | 0.60 |
| ▸ | POLB | P06746 | 2/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.60 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.59 |
| ▸ | EPHX2 | P34913 | 5/20 | 0.53 |
| ▸ | LTA4H | P09960 | 4/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | PLAAT3 | P53816 | 2/20 | 0.46 |
| ▸ | PLAAT5 | Q96KN8 | 2/20 | 0.46 |
| ▸ | PLAAT2 | Q9NWW9 | 2/20 | 0.46 |
| ▸ | PLAAT4 | Q9UL19 | 2/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2875788 | 0.97 | ALDH1A1 (0.64) | ALDH1A1KDM4EHSD17B10HPGDMAPT | |
| SCHEMBL2869386 | 0.91 | ALDH1A1 (0.67) | ALDH1A1KDM4EHSD17B10HPGDMAPT | |
| SCHEMBL2870661 | 0.91 | ALDH1A1 (0.67) | ALDH1A1KDM4EHSD17B10HPGDMAPT | |
| SCHEMBL2874169 | 0.89 | ALDH1A1 (0.59) | ALDH1A1KDM4EHSD17B10HPGDMAPT | |
| SCHEMBL2874485 | 0.88 | ALDH1A1 (0.58) | ALDH1A1KDM4EHSD17B10HPGDMAPT | |
| SCHEMBL2872656 | 0.87 | ALDH1A1 (0.72) | ALDH1A1KDM4EHSD17B10HPGDMAPT | |
| SCHEMBL2865063 | 0.87 | ALDH1A1 (0.60) | ALDH1A1KDM4EHSD17B10HPGDMAPT | |
| SCHEMBL2873310 | 0.87 | ALDH1A1 (0.57) | ALDH1A1KDM4EHSD17B10HPGDMAPT | |
| SCHEMBL2867675 | 0.86 | KDM4E (0.54) | ALDH1A1KDM4EHSD17B10HPGDMAPT | |
| SCHEMBL2874358 | 0.85 | ALDH1A1 (0.56) | ALDH1A1KDM4EHSD17B10HPGDMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050245586-A1 | 2,5-Dioxoimidazolidin-4-yl acetamides and analogues as inhibitors of metalloproteinase mmp12 | ASTRAZENECA AB (SE) | 2005-11-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050245586-A1 | 2,5-Dioxoimidazolidin-4-yl acetamides and analogues as inhibitors of metalloproteinase mmp12 | MMP12, PDE12, MMP13 | ALDH1A1 441/4885KDM4E 553/4885HSD17B10 1312/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.