SCHEMBL652827

SCHEMBL652827

CCCc1cc(C(=O)N[C@H](Cc2ccccc2)[C@@H](O)C(=O)O)nn1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(C)C)cc1

nearest known ligand 0.44

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
AGTR2 P50052 8/20 0.43
AGTR1 P30556 5/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL650853 0.96 AGTR2 (0.43) AGTR2AGTR1
SCHEMBL656869 0.96 AGTR2 (0.43) AGTR2AGTR1
SCHEMBL656868 0.96 AGTR2 (0.43) AGTR2AGTR1
SCHEMBL652670 0.93 AGTR2 (0.42) AGTR2AGTR1
SCHEMBL994431 0.92 AGTR2 (0.45) AGTR2AGTR1
SCHEMBL653073 0.92 AGTR2 (0.45) AGTR2AGTR1
SCHEMBL656488 0.92 AGTR2 (0.50) AGTR2
SCHEMBL650654 0.91 AGTR2 (0.43) AGTR2AGTR1
SCHEMBL671768 0.91 AGTR2 (0.47) AGTR2AGTR1
SCHEMBL652375 0.91 AGTR2 (0.49) AGTR2AGTR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220016219-A1 Means and Methods to Treat Diabetes EBERHARD KARLS UNIVERSITAET TUEBINGEN MEDIZINISCHE FAKULTAET (DE) 2022-01-20 US claimed
WO-2020157264-A1 IMPROVED MEANS AND METHODS TO TREAT DIABETES EBERHARD KARLS UNIVERSITÄT TÜBINGEN MEDIZINISCHE FAKULTÄT (DE) 2020-08-06 WO claimed
EP-3689367-A1 IMPROVED MEANS AND METHODS TO TREAT DIABETES Eberhard Karls Universität Tübingen Medizinische Fakultät (DE) 2020-08-05 EP claimed
EP-3202494-B1 PROCESS FOR EPOXIDATION AND CATALYST TO BE USED THEREIN BASF SE (DE) 2019-08-21 EP disclosed
EP-3202494-A1 PROCESS FOR EPOXIDATION AND CATALYST TO BE USED THEREIN BASF SE (DE) 2017-08-09 EP disclosed
EP-2451782-B1 DUAL-ACTING PYRAZOLE ANTIHYPERTENSIVE AGENTS THERAVANCE BIOPHARMA R&D IP LLC (US) 2016-11-09 EP disclosed
US-8822522-B2 Dual-acting pyrazole antihypertensive agents THERAVANCE BIOPHARMA R&D IP, LLC (US) 2014-09-02 US disclosed
US-20130245041-A1 DUAL-ACTING PYRAZOLE ANTIHYPERTENSIVE AGENTS THERAVANCE BIOPHARMA R&D IP, LLC 2013-09-19 US disclosed
US-8350027-B2 Dual-acting pyrazole antihypertensive agents THERAVANCE, INC. (US) 2013-01-08 US disclosed
US-8119550-B2 Zeolite; separation from mother liquor; roasting BASF AKTIENGESELLSCHAFT (DE) 2012-02-21 US disclosed
US-8119634-B2 Dual-acting pyrazole antihypertensive agents THERAVANCE, INC. (US) 2012-02-21 US disclosed
EP-1549433-A1 IMPROVED CATALYST FOR EPOXIDATION REACTIONS BASF AKTIENGESELLSCHAFT (DE) 2005-07-06 EP disclosed
EP-1545771-A1 PROCESS FOR EPOXIDATION AND CATALYST TO BE USED THEREIN BASF AKTIENGESELLSCHAFT (DE) 2005-06-29 EP disclosed
US-6884743-B2 Catalyst for epoxidation reactions BASF AKTIENGESELLSCHAFT (DE) 2005-04-26 US disclosed
US-20050085646-A1 Process for epoxidation and catalyst to be used therein BASF AKTIENGESELLSCHAFT (DE) 2005-04-21 US disclosed
US-20050054865-A1 A mixture of titanium tetraalkoxide and alkylene diols the reaction product of which catalyzes the depolymerization of a blend polyesters to give a gel-free mixture of cyclic homopolymers free of any cyclic copolymers; purity; molding materials intermediates;auto paints BASF AKTIENGESELLSCHAFT (DE) 2005-03-10 US disclosed
WO-2004026467-A1 PROCESS FOR EPOXIDATION AND CATALYST TO BE USED THEREIN BASF AKTIENGESELLSCHAFT (DE) 2004-04-01 WO disclosed
WO-2004024321-A1 IMPROVED CATALYST FOR EPOXIDATION REACTIONS BASF AKTIENGESELLSCHAFT (DE) 2004-03-25 WO disclosed
US-20040053772-A1 Crystallizing a zeolite solids comprising silica and titania, improving catalyst selectivity, for reacting propylene and hydrogen peroxide to propylene oxide BASF AKTIENGESELLSCHAFT (DE) 2004-03-18 US disclosed
US-20040054199-A1 Process for epoxidation and catalyst to be used therein BASF AKTIENGESELLSCHAFT (DE) 2004-03-18 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130245041-A1 DUAL-ACTING PYRAZOLE ANTIHYPERTENSIVE AGENTS AGTR1, AGTR2, REN AGTR2 2/4885AGTR1 1/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.