Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPSE | Q9Y251 | 9/20 | 0.77 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6506649 | 0.85 | HPSE (0.80) | HPSEKDM4ENPC1ALDH1A1TP53 | |
| SCHEMBL6529592 | 0.81 | HPSE (1.00) | HPSEPRMT5 | |
| SCHEMBL6258154 | 0.81 | HPSE (0.81) | HPSEPRMT5KDM4ENPC1ALDH1A1 | |
| SCHEMBL6529350 | 0.79 | HPSE (1.00) | HPSEKDM4ENPC1ALDH1A1TP53 | |
| SCHEMBL6244081 | 0.75 | PRMT5 (1.00) | HPSEPRMT5NPC1RAB9A | |
| SCHEMBL11770396 | 0.72 | AURKA (0.70) | HPSEPRMT5NPC1HPGDRAB9A | |
| SCHEMBL6529731 | 0.72 | HPSE (0.78) | HPSEKDM4ENPC1ALDH1A1TP53 | |
| SCHEMBL14022276 | 0.71 | HPSE (0.65) | HPSEPRMT5 | |
| SCHEMBL6529477 | 0.71 | HPSE (1.00) | HPSEKDM4ENPC1ALDH1A1TP53 | |
| SCHEMBL13405867 | 0.71 | KDM4E (1.00) | HPSEKDM4ENPC1ALDH1A1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005042495-A1 | (BENZIMIDAZOL-2-YL)-PHENYL-PHENYL-UREA COMPOUNDS AND METHODS FOR INHIBITING HEPARANASE ACTIVITY | IMCLONE SYSTEMS INCORPORATED (US) | 2005-05-12 | — | — | WO | disclosed |