Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPSE | Q9Y251 | 2/20 | 0.81 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.72 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.65 |
| ▸ | TP53 | P04637 | 2/20 | 0.65 |
| ▸ | HPGD | P15428 | 2/20 | 0.65 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.65 |
| ▸ | NPC1 | O15118 | 1/20 | 0.65 |
| ▸ | RAB9A | P51151 | 1/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.65 |
| ▸ | PARP1 | P09874 | 1/20 | 0.60 |
| ▸ | DHODH | Q02127 | 1/20 | 0.60 |
| ▸ | AURKA | O14965 | 3/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9043085 | 0.86 | KDM4E (0.68) | HPSEPRMT5KDM4EALDH1A1TP53 | |
| SCHEMBL6244081 | 0.84 | PRMT5 (1.00) | HPSEPRMT5NPC1RAB9AAURKA | |
| SCHEMBL6529592 | 0.83 | HPSE (1.00) | HPSEPRMT5 | |
| SCHEMBL14022276 | 0.82 | HPSE (0.65) | HPSEPRMT5AURKA | |
| SCHEMBL6528618 | 0.81 | HPSE (0.77) | HPSEPRMT5KDM4EALDH1A1TP53 | |
| SCHEMBL2244714 | 0.80 | HPSE (0.79) | HPSEKDM4EALDH1A1TP53HPGD | |
| SCHEMBL23999972 | 0.79 | KDM4E (0.60) | HPSEPRMT5KDM4EALDH1A1TP53 | |
| SCHEMBL13405867 | 0.79 | KDM4E (1.00) | HPSEKDM4EALDH1A1TP53HPGD | |
| SCHEMBL14022277 | 0.78 | PRMT5 (0.67) | HPSEPRMT5KDM4EALDH1A1HPGD | |
| SCHEMBL29066590 | 0.77 | LMNA (0.60) | HPSEPRMT5KDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005030206-A1 | ARYL-1,3-AZOLE DERIVATIVES AND METHODS FOR INHIBITING HEPARNASE ACTIVITY | IMCLONE SYSTEMS INCORPORATED (US) | 2005-04-07 | — | — | WO | disclosed |
| EP-0700906-A1 | Heterocyclic derivatives of N-phenylamides | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-03-13 | — | — | EP | disclosed |
| US-5496826-A | ANTICONVULSANTS, MELATONERGIC AGENTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-03-05 | — | — | US | disclosed |