Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 10/20 | 0.72 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.72 |
| ▸ | LMNA | P02545 | 2/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.47 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6529147 | 0.87 | MAPT (0.68) | MAPTL3MBTL1LMNAPOLBALDH1A1 | |
| SCHEMBL2041681 | 0.85 | MAPT (0.79) | MAPTL3MBTL1LMNAPOLBALDH1A1 | |
| SCHEMBL3958300 | 0.85 | MAPT (0.65) | MAPTL3MBTL1LMNAPOLBALDH1A1 | |
| SCHEMBL3534109 | 0.81 | LMNA (0.71) | MAPTL3MBTL1LMNAPOLBALDH1A1 | |
| SCHEMBL30784585 | 0.81 | MAPT (0.72) | MAPTL3MBTL1LMNAPOLBALDH1A1 | |
| SCHEMBL3536097 | 0.79 | LMNA (0.73) | MAPTL3MBTL1LMNAPOLBALDH1A1 | |
| SCHEMBL3958592 | 0.79 | MAPT (0.73) | MAPTL3MBTL1LMNAPOLBALDH1A1 | |
| SCHEMBL3435998 | 0.78 | MAPT (0.74) | MAPTL3MBTL1LMNAPOLBALDH1A1 | |
| SCHEMBL2269393 | 0.77 | MAPT (0.55) | MAPTL3MBTL1LMNAPOLBALDH1A1 | |
| SCHEMBL2952969 | 0.76 | ALDH1A1 (0.67) | MAPTLMNAALDH1A1TDP1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005019200-A2 | ARYL PIPERIDINE DERIVATIVES AS VLA-1 INTEGRIN ANTAGONISTS AND USES THEREOF | ICOS CORPORATION (US) | 2005-03-03 | — | — | WO | disclosed |